Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502328 | 0.87 | RARB (0.42) | LMNACNR2RARB | |
| SCHEMBL6532172 | 0.86 | LTA4H (0.42) | CNR2LTA4HTHRATHRBPDE4A | |
| SCHEMBL6530992 | 0.84 | LMNA (0.40) | LMNARARBMMP9MMP8MMP13 | |
| SCHEMBL6529005 | 0.84 | PTPN11 (0.40) | LMNACNR2CNR1LTA4HTHRA | |
| SCHEMBL6529689 | 0.82 | LMNA (0.37) | LMNARARB | |
| SCHEMBL6530514 | 0.80 | FDFT1 (0.41) | LMNAPLA2G4B | |
| SCHEMBL6530174 | 0.78 | LMNA (0.39) | LMNACNR2CNR1RARBMMP9 | |
| SCHEMBL6504727 | 0.78 | S1PR1 (0.45) | RARBMEN1ALDH1A1KMT2A | |
| SCHEMBL6529532 | 0.77 | S1PR1 (0.44) | RARBLTA4HTHRATHRBPDE4A | |
| SCHEMBL6529916 | 0.77 | CYP2D6 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014525-A2 | BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY | MITSUBISHI PHARMA CORPORATION (JP) | 2005-02-17 | — | — | WO | disclosed |