SCHEMBL65489

SCHEMBL65489

CCNc1cc[nH]c(=O)n1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 3/20 0.42
SCN5A Q14524 3/20 0.42
KCNH2 Q12809 2/20 0.42
ELANE P08246 2/20 0.40
HCAR3 P49019 1/20 0.36
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
ALDH1A1 P00352 1/20 0.33
POLB P06746 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
CNR1 P21554 1/20 0.33
AURKA O14965 1/20 0.33
PDPK1 O15530 1/20 0.33
TGFBR1 P36897 1/20 0.33
AURKB Q96GD4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL28720905 0.88 CACNA1C (0.39) CACNA1CSCN5AKCNH2ELANEKDM4C
SCHEMBL4113139 0.85 ELANE (0.43) ELANEHCAR3ALDH1A1CA1CA2
Triphosphate SCHEMBL8441046 0.83 P2RY2 (0.35) CACNA1CSCN5AKCNH2ELANEHCAR3
SCHEMBL29509040 0.82 TLR8 (0.49) ELANEHCAR3ALDH1A1CA1CA2
SCHEMBL606375 0.80 ELANE (0.46) ELANEHCAR3CNR1
SCHEMBL19692262 0.80 ALDH1A1 (0.33) ADORA2AADORA1ALDH1A1POLB
SCHEMBL236001 0.80 ALDH1A1 (0.33) ADORA2AADORA1ALDH1A1POLB
SCHEMBL17372301 0.80 ALDH1A1 (0.33) ADORA2AADORA1ALDH1A1POLB
SCHEMBL30688742 0.79 ESR1 (0.46) HCAR3
SCHEMBL18660242 0.79 KCNH3 (0.36) ADORA2AADORA1ALDH1A1POLBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1717 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106907-A1 FAST PCR BY TANDEM PRIMER EMBEDDED WITH RIBONUCLEOTIDE CEPHEID (US) 2026-05-21 WO claimed
US-20260117214-A1 Prime Editing Systems having pegRNA with Reduced Auto-inhibitory Interaction UNIV MASSACHUSETTS (US) 2026-04-30 US claimed
EP-4689099-A1 PRIME EDITING SYSTEMS HAVING PEGRNA WITH REDUCED AUTO-INHIBITORY INTERACTION University of Massachusetts (US) 2026-02-11 EP claimed
US-12460256-B1 Nucleotide analogs for efficient DNA and RNA amplification BENNER STEVEN A (US) 2025-11-04 US claimed
EP-4558641-A1 METHODS FOR DETECTION AND REDUCTION OF SAMPLE PREPARATION-INDUCED METHYLATION ARTIFACTS Guardant Health, Inc. (US) 2025-05-28 EP claimed
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2025-02-27 US claimed
WO-2024220135-A1 PRIME EDITING SYSTEMS HAVING PEGRNA WITH REDUCED AUTO-INHIBITORY INTERACTION UNIVERSITY OF MASSACHUSETTS (US) 2024-10-24 WO claimed
CN-112105627-B Unnatural base pair compositions and methods of use 斯克利普斯研究所 2024-07-02 CN claimed
CN-117778530-A Method for adding preset joint to 5' end of single-stranded DNA 清华大学 2024-03-29 CN claimed
WO-2024020573-A1 METHODS FOR DETECTION AND REDUCTION OF SAMPLE PREPARATION-INDUCED METHYLATION ARTIFACTS GUARDANT HEALTH, INC. (US) 2024-01-25 WO claimed
US-20040097719-A1 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends HYBRIDON, INC. 2004-05-20 US claimed
JP-2004509970-A 2004-04-02 JP claimed
EP-1393745-A1 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5'ends HYBRIDON, INC. (US) 2004-03-03 EP claimed
WO-2004016805-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-02-26 WO claimed
WO-2003057822-A2 MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY OPTIMAL PRESENTATION OF 5' ENDS HYBRIDON, INC. (US) 2003-07-17 WO claimed
EP-1322656-A2 MODULATION OF IMMUNOSTIMULATORY ACTIVITY OF IMMUNOSTIMULATORY OLIGONUCLEOTIDE ANALOGS BY POSITIONAL CHEMICAL CHANGES HYBRIDON, INC. (US) 2003-07-02 EP claimed
WO-2003035836-A2 MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY OPTIMAL PRESENTATION OF 5' ENDS HYBRIDON INC. (US) 2003-05-01 WO claimed
US-20020137714-A1 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes IDERA PHARMACEUTICALS, INC 2002-09-26 US claimed
WO-2002026757-A2 MODULATION OF IMMUNOSTIMULATORY ACTIVITY OF IMMUNOSTIMULATORY OLIGONUCLEOTIDE ANALOGS BY POSITIONAL CHEMICAL CHANGES HYBRIDON, INC. (US) 2002-04-04 WO claimed
WO-1998000564-A1 METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC HYBRIDIZATION OF RNA BY 2'-5' OLIGONUCLEOTIDES DYAD PHARMACEUTICAL CORPORATION (US) 1998-01-08 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260117214-A1 Prime Editing Systems having pegRNA with Reduced Auto-inhibitory Interaction SSU72, ADAR, UPF1 CACNA1C 4804/4885SCN5A 3982/4885KCNH2 4862/4885
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE RNGTT, SPOUT1, NPEPPS CACNA1C 4721/4885SCN5A 4215/4885KCNH2 4315/4885
US-20020137714-A1 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes STING1, IRF3, TLR9 CACNA1C 4834/4885SCN5A 4292/4885KCNH2 4674/4885
US-20040097719-A1 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends TLR5, TLR3, ENTPD5 CACNA1C 4856/4885SCN5A 2047/4885KCNH2 4624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.