Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6553813 | 0.92 | MMP2 (0.48) | TDP1KMT2ALTB4RSLC6A2SLC6A3 | |
| SCHEMBL7042642 | 0.92 | ALOX5 (0.57) | TDP1KMT2ALTB4RSLC6A2SLC6A3 | |
| SCHEMBL6552425 | 0.83 | LTB4R (0.57) | KMT2ALTB4RALDH1A1TSHR | |
| SCHEMBL22292189 | 0.77 | RAB9A (0.52) | TDP1KMT2ASLC6A2SLC6A3MMP2 | |
| SCHEMBL21240753 | 0.77 | DAGLA (0.54) | TDP1KMT2ASLC6A2SLC6A3MMP2 | |
| SCHEMBL7047760 | 0.75 | LTB4R (0.49) | TDP1KMT2ALTB4RALDH1A1LMNA | |
| SCHEMBL7044996 | 0.75 | TRPM8 (0.46) | TDP1KMT2AALOX5ALDH1A1LMNA | |
| SCHEMBL22048694 | 0.73 | LTB4R (0.50) | LTB4RALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL4701791 | 0.73 | ALDH1A1 (0.57) | LTB4RALOX5ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14768871 | 0.72 | TDP1 (0.66) | TDP1KMT2ASLC6A2SLC6A3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | claimed |
| EP-1482794-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | Merck & Co., Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075660-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | MERCK & CO., INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |