SCHEMBL65614

SCHEMBL65614

CNc1nc2nc(C)[nH]c2c(=O)[nH]1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.40
FGFR1 P11362 2/20 0.38
FGFR2 P21802 2/20 0.38
PNP P00491 2/20 0.38
FGFR3 P22607 1/20 0.37
XDH P47989 3/20 0.37
NUDT1 P36639 1/20 0.35
TYMS P04818 1/20 0.35
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
CSNK2A1 P68400 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26155922 0.82 PNP (0.48) PNPNUDT1CSNK2A1
SCHEMBL8591402 0.81 FGFR1 (0.51) GDAFGFR1FGFR2PNPFGFR3
SCHEMBL11567738 0.80 FGFR1 (0.38) GDAFGFR1FGFR2PNPFGFR3
SCHEMBL16513137 0.80 GDA (0.64) GDAFGFR1FGFR2FGFR3
SCHEMBL9275474 0.77 XDH (0.38) GDAFGFR1FGFR2PNPFGFR3
SCHEMBL6270959 0.76 FYN (0.52) CSNK2A1
SCHEMBL16513140 0.76 MAPT (0.50) FGFR1FGFR2PNP
SCHEMBL22885 0.75 GDA (0.68) GDAPNPXDH
SCHEMBL5133744 0.75 XDH (0.39) GDAFGFR1FGFR2PNPFGFR3
SCHEMBL4384740 0.75 XDH (0.67) PNPXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 687 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12584924-B2 Compositions and methods for diagnosing and treating chronic kidney disease SOCIETE DES PRODUITS NESTLE S.A. (CH) 2026-03-24 US claimed
US-20230204604-A1 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CHRONIC KIDNEY DISEASE SOCIETE DES PRODUITS NESTLE S.A. (CH) 2023-06-29 US claimed
US-10968248-B2 Trinucleotide mRNA cap analogs Arcturus, Inc. (US) 2021-04-06 US claimed
US-20200040026-A1 TRINUCLEOTIDE MRNA CAP ANALOGS ARCTURUS THERAPEUTICS, INC. 2020-02-06 US claimed
EP-2179039-B1 RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES ZOETIS BELGIUM S A (BE) 2018-10-31 EP claimed
US-9284343-B2 2′-O-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-03-15 US claimed
EP-2451475-A2 SELF REPLICATING RNA MOLECULES AND USES THEREOF Novartis AG (CH) 2012-05-16 EP claimed
US-20110300205-A1 SELF REPLICATING RNA MOLECULES AND USES THEREOF NOVARTIS AG (CH) 2011-12-08 US claimed
WO-2011005799-A2 SELF REPLICATING RNA MOLECULES AND USES THEREOF NOVARTIS AG (CH) 2011-01-13 WO claimed
CN-101821392-A RNA sequence motifs inducing specific immunomodulatory properties in a defined internucleotide linkage environment COLEY PHARM GMBH 2010-09-01 CN claimed
WO-2009022216-A2 RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES COLEY PHARMACEUTICAL GMBH (US) 2009-02-19 WO claimed
WO-2008033432-A2 IMMUNE MODULATION BY CHEMICALLY MODIFIED RIBONUCLEOSIDES AND OLIGORIBONUCLEOTIDES COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-03-20 WO claimed
EP-1899467-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceutical GmbH (DE) 2008-03-19 EP claimed
CN-1973821-A Medicine composition containing both anticancer medicine and its synergist SHANDONG LANJIN BIOENGINEERING (CN) 2007-06-06 CN claimed
WO-2006116458-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY COLEY PHARMACEUTICAL GMBH (DE) 2006-11-02 WO claimed
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2006-10-26 US claimed
US-20050239727-A1 for use in cosmetics, drugs SILDEHA SWISS SA (CH) 2005-10-27 US claimed
EP-1525224-A1 HYALURONIC ACID DERIVATIVES Jasper Ltd. Liability Co. (US) 2005-04-27 EP claimed
EP-1518854-A1 Substituted 06- benzylguanines and 7- or 9- substituted 8-aza-06-benzylguanines THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 2005-03-30 EP claimed
WO-2004013182-A1 HYALURONIC ACID DERIVATIVES JASPER LTD LIABILITY CO. (US) 2004-02-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050239727-A1 for use in cosmetics, drugs HINT1, NUDT1, NNT GDA 50/4885FGFR1 761/4885FGFR2 1390/4885
US-20200040026-A1 TRINUCLEOTIDE MRNA CAP ANALOGS RNGTT, RNMT, NSUN2 GDA 821/4885FGFR1 4273/4885FGFR2 4657/4885
US-10968248-B2 Trinucleotide mRNA cap analogs RNGTT, RNMT, NSUN2 GDA 821/4885FGFR1 4273/4885FGFR2 4657/4885
US-12584924-B2 Compositions and methods for diagnosing and treating chronic kidney disease GLS, AADAT, FGF23 GDA 1197/4885FGFR1 547/4885FGFR2 658/4885
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity TLR3, TLR8, TLR9 GDA 299/4885FGFR1 934/4885FGFR2 2158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.