Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.51 |
| ▸ | FABP4 | P15090 | 4/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | RORB | Q92753 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.43 |
| ▸ | MICA | Q29983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542609 | 0.81 | PTGER1 (0.56) | PDK2RORBEIF4EAKR1C3AKR1C2 | |
| SCHEMBL31161066 | 0.80 | CHRM1 (0.53) | KMOPDK2FABP4FABP3EIF4E | |
| SCHEMBL6562403 | 0.79 | KMO (0.45) | KMOFABP4SCN9AAKR1C3AKR1C2 | |
| SCHEMBL4881566 | 0.78 | ALDH1A1 (0.58) | PDK2EIF4EAKR1C2RAB9AALDH1A1 | |
| SCHEMBL23354547 | 0.77 | FTO (0.53) | KMOPDK2EIF4EAKR1C2ALDH1A1 | |
| SCHEMBL6639868 | 0.76 | PRKAB2 (0.44) | KMOPDK2FABP4RORCRORB | |
| SCHEMBL1041026 | 0.76 | ESR2 (0.52) | KMOPDK2 | |
| Xenalipin SCHEMBL29881739 | 0.74 | CYP2C8 (0.58) | KLRK1MICA | |
| Xenalipin SCHEMBL133087 | 0.74 | CYP2C8 (0.58) | KLRK1MICA | |
| SCHEMBL22452977 | 0.74 | TAS2R14 (0.55) | FABP4CLCN2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398120-B2 | Substituted hydantoinamides as ADAMTS7 antagonists | BAYER AKTIENGESELLSCHAFT (DE) | 2025-08-26 | — | — | US | disclosed |
| EP-4058448-B1 | HYDANTOIN DERIVATIVES AS ADAMTS7 ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER AG (DE) | 2024-05-29 | — | — | EP | disclosed |
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-01-26 | — | — | US | disclosed |
| EP-3822268-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2021-05-19 | — | — | EP | disclosed |
| EP-1223158-B1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | BAYER CHEMICALS AG (DE) | 2004-08-11 | — | — | EP | disclosed |
| US-6580002-B2 | Dihalo-, cyano- and methyl- substituted biphenyl chemical intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 2003-06-17 | — | — | US | disclosed |
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | LANXESS DEUTSCHLAND GMBH (DE) | 2003-03-20 | — | — | US | disclosed |
| US-6465688-B2 | CONVERTING METHYL-SUBSTITUTED BIPHENYLCARBONITRILES TO A TRICHLOROMETHYL- AND HYDROLYZING TO CORRESPONDING CARBOXY ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-15 | — | — | US | disclosed |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | LANXESS DEUTSCHLAND GMBH (DE) | 2002-07-18 | — | — | US | disclosed |
| EP-1223158-A1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | Bayer Aktiengesellschaft (DE) | 2002-07-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12398120-B2 | Substituted hydantoinamides as ADAMTS7 antagonists | ADAMTS7, MMP7, ADAM17 | KMO 728/4885PDK2 2446/4885FABP4 4725/4885 |
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | CPSF1, CYP2F1, CYP4F2 | KMO 122/4885PDK2 1279/4885FABP4 766/4885 |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | MCCC2, CYP2F1, CYP4F2 | KMO 82/4885PDK2 1167/4885FABP4 477/4885 |
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | ADAMTS7, MMP7, ADAM17 | KMO 728/4885PDK2 2446/4885FABP4 4725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.