SCHEMBL66251

SCHEMBL66251

Brc1ccc(-c2ccc(N(c3ccccc3-c3ccccc3)c3ccccc3-c3ccccc3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.54
MAPK1 P28482 2/20 0.54
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
SLC6A3 Q01959 1/20 0.38
NR1H4 Q96RI1 1/20 0.35
PTPRC P08575 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
NR1H2 P55055 2/20 0.33
NR1H3 Q13133 2/20 0.33
HPGD P15428 2/20 0.33
MCL1 Q07820 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
CES2 O00748 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5918737 1.00 ALDH1A1 (0.54) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL4608172 0.96 ALDH1A1 (0.54) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL16577756 0.96 ALDH1A1 (0.54) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL15662815 0.96 ALDH1A1 (0.54) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL15662355 0.96 ALDH1A1 (0.54) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL5918721 0.96 ALDH1A1 (0.46) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL17700993 0.95 ALDH1A1 (0.52) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL15525343 0.93 ALDH1A1 (0.46) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL18859311 0.91 ALDH1A1 (0.45) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL18023716 0.91 MAPK1 (0.44) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11751472-B2 Aromatic amine derivative and elecroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2023-09-05 US disclosed
US-11538997-B2 Aromatic amine derivative and electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2022-12-27 US disclosed
US-20220336749-A9 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD (JP) 2022-10-20 US disclosed
US-20220271231-A1 AROMATIC AMINE DERIVATIVE AND ELECROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2022-08-25 US disclosed
US-10446761-B2 Aromatic amine derivative and electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2019-10-15 US disclosed
US-20190081245-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2019-03-14 US disclosed
US-10158084-B2 Aromatic amine derivative and electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2018-12-18 US disclosed
US-10153435-B2 Aromatic amine derivative and electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2018-12-11 US disclosed
US-20170294588-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2017-10-12 US disclosed
US-20160351821-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2016-12-01 US disclosed
US-20080303417-A1 Aromatic Amine Derivative and Organic Electroluminescent Device Using Same IDEMITSU KOSAN CO., LTD. (JP) 2008-12-11 US disclosed
US-20080108839-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2008-05-08 US disclosed
US-20080106190-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2008-05-08 US disclosed
US-20080108832-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2008-05-08 US disclosed
US-20080108811-A1 Aromatic Amine Derivative and Organic Electroluminescent Device Using Same IDEMITSU KOSAN CO., LTD. (JP) 2008-05-08 US disclosed
US-20070278938-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-12-06 US disclosed
EP-1834946-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-09-19 EP disclosed
EP-1834945-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-09-19 EP disclosed
US-20060134458-A1 Aromatic amine derivative and organic electroluminescence element IDEMITSU KOSAN CO., LTD. (JP) 2006-06-22 US disclosed
EP-1584614-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2005-10-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070278938-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME MAOA, SETD1A, EML4 ALDH1A1 351/4885MAPK1 1836/4885NPC1 4642/4885
US-10446761-B2 Aromatic amine derivative and electroluminescence device using the same EML4, DDC, TYR ALDH1A1 470/4885MAPK1 1977/4885NPC1 4716/4885
US-11751472-B2 Aromatic amine derivative and elecroluminescence device using the same ALK, ALKBH3, ACVRL1 ALDH1A1 177/4885MAPK1 2476/4885NPC1 4823/4885
US-20080108839-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME EML4, SLC18A2, SLC18A3 ALDH1A1 1045/4885MAPK1 2500/4885NPC1 2257/4885
US-20080106190-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME EML4, SLC18A2, SLC18A3 ALDH1A1 1118/4885MAPK1 2341/4885NPC1 2160/4885
US-20190081245-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME EML4, DDC, TYR ALDH1A1 470/4885MAPK1 1977/4885NPC1 4716/4885
US-20080108832-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME ALKBH3, EML4, ALKBH2 ALDH1A1 1034/4885MAPK1 2102/4885NPC1 4066/4885
US-20170294588-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME MAOA, SETD1A, EML4 ALDH1A1 351/4885MAPK1 1836/4885NPC1 4642/4885
US-11538997-B2 Aromatic amine derivative and electroluminescence device using the same EML4, DDC, TYR ALDH1A1 470/4885MAPK1 1977/4885NPC1 4716/4885
US-20160351821-A1 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME MAOA, SETD1A, EML4 ALDH1A1 351/4885MAPK1 1836/4885NPC1 4642/4885
US-20220271231-A1 AROMATIC AMINE DERIVATIVE AND ELECROLUMINESCENCE DEVICE USING THE SAME ALK, ALKBH3, ACVRL1 ALDH1A1 177/4885MAPK1 2476/4885NPC1 4823/4885
US-20080108811-A1 Aromatic Amine Derivative and Organic Electroluminescent Device Using Same ALKBH2, ALKBH3, SETD1A ALDH1A1 779/4885MAPK1 2497/4885NPC1 4594/4885
US-10153435-B2 Aromatic amine derivative and electroluminescence device using the same MAOA, SETD1A, EML4 ALDH1A1 351/4885MAPK1 1836/4885NPC1 4642/4885
US-20060134458-A1 Aromatic amine derivative and organic electroluminescence element TYR, SLC18A1, MAOA ALDH1A1 689/4885MAPK1 2465/4885NPC1 4299/4885
US-10158084-B2 Aromatic amine derivative and electroluminescence device using the same MAOA, SETD1A, EML4 ALDH1A1 316/4885MAPK1 1712/4885NPC1 4667/4885
US-20220336749-A9 AROMATIC AMINE DERIVATIVE AND ELECTROLUMINESCENCE DEVICE USING THE SAME EML4, DDC, TYR ALDH1A1 470/4885MAPK1 1977/4885NPC1 4716/4885
US-20080303417-A1 Aromatic Amine Derivative and Organic Electroluminescent Device Using Same DDC, AOC2, ALKBH2 ALDH1A1 238/4885MAPK1 2882/4885NPC1 4775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.