Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678578 | 0.91 | MAPT (0.42) | HTTSMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL6689991 | 0.91 | MAPT (0.41) | HTTSMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL6679654 | 0.88 | TRPM8 (0.45) | HTTSMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL6698055 | 0.83 | ALDH1A1 (0.42) | HTTSMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL6677935 | 0.83 | KCNK3 (0.40) | HSD17B2HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL6683423 | 0.79 | MAPT (0.48) | SMN1; SMN2MAPTMEN1LMNAKMT2A | |
| SCHEMBL6689149 | 0.78 | GPR139 (0.39) | HSD17B2HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL28830806 | 0.75 | HPGDS (0.68) | HSD17B2SMN1; SMN2MEN1KMT2ATRPM8 | |
| SCHEMBL4916663 | 0.73 | FGFR2 (0.37) | HTTSMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL6677495 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTMAPK1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | claimed |
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | disclosed |