Sugi Predict

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SCHEMBL678646

SCHEMBL678646

COc1cc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.79
▸ CYP3A4 P08684 4/20 0.79
▸ MAPT P10636 3/20 0.79
▸ MEN1 O00255 3/20 0.79
▸ KMT2A Q03164 3/20 0.79
▸ KDM4E B2RXH2 2/20 0.79
▸ MAPK1 P28482 2/20 0.79
▸ ABCB1 P08183 2/20 0.79
▸ ABCG2 Q9UNQ0 2/20 0.79
▸ HPGD P15428 1/20 0.79
▸ HSD17B10 Q99714 1/20 0.79
▸ POLB P06746 1/20 0.76
▸ GAA P10253 1/20 0.76
▸ RECQL P46063 1/20 0.76
▸ L3MBTL1 Q9Y468 1/20 0.76
▸ USP2 O75604 1/20 0.72
▸ LMNA P02545 1/20 0.72
▸ ELANE P08246 1/20 0.72
▸ HSD17B2 P37059 1/20 0.67
▸ TAS2R31 P59538 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30082747 1.00 ALDH1A1 (0.79) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL10997922 0.93 ALDH1A1 (0.80) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL10997058 0.93 ALDH1A1 (0.88) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL684139 0.90 ALDH1A1 (0.72) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL20530430 0.90 ALDH1A1 (0.84) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL1764091 0.90 ALDH1A1 (0.79) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL30082749 0.90 ALDH1A1 (0.79) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL1764426 0.90 BCL2 (0.79) ALDH1A1CYP3A4MAPTMEN1KMT2A
SCHEMBL30445844 0.90 BCL2 (0.79) ALDH1A1CYP3A4MAPTMEN1KMT2A
Nobiletin SCHEMBL22092292 0.88 ALDH1A1 (1.00) ALDH1A1CYP3A4MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240114939-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONES AND THEIR USE FIRMENICH SA (CH) 2024-04-11 — — US claimed
US-20140039044-A1 Hydroxylated Polymethoxyflavone Compositions WLLGEN, INC. (US) 2014-02-06 — — US claimed
EP-2494874-B1 Control of flavor characteristics of fruit juice TROPICANA PROD INC (US) 2013-12-11 — — EP claimed
EP-2494874-A1 Control of flavor characteristics of fruit juice TROPICANA PRODUCTS, INC. (US) 2012-09-05 — — EP claimed
US-20110287106-A1 COGNITIVE IMPAIRMENT AMELIORANT JAPAN ROYAL JELLEY CO., LTD. (JP) 2011-11-24 — — US claimed
EP-2311472-A1 COGNITIVE DISORDER-AMELIORATING AGENT Japan Royal Jelly Co., Ltd. (JP) 2011-04-20 — — EP claimed
EP-2010194-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS Rutgers, The State University of New Jersey (US) 2009-01-07 — — EP claimed
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions WELLGEN, INC. 2007-11-29 — — US claimed
WO-2007109071-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-09-27 — — WO claimed
US-20240114939-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONES AND THEIR USE FIRMENICH SA (CH) 2024-04-11 — — US disclosed
EP-4258899-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONES AND THEIR USE Firmenich SA (CH) 2023-10-18 — — EP disclosed
WO-2022189155-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONES AND THEIR USE FIRMENICH SA (CH) 2022-09-15 — — WO disclosed
US-8980352-B2 Control of flavor characteristics of and indicator of freshness in fruit juice TROPICANA PRODUCTS, INC. (US) 2015-03-17 — — US disclosed
US-8940789-B2 Neurite elongation agent, memory-improving agent and anti-Alzheimer agent comprising 4′-demethylnobiletin or 4′-demethyltangeretin as active ingredient, and process for production of the compound FUJI SANGYO CO., LTD. (JP) 2015-01-27 — — US disclosed
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions WELLGEN, INC. 2007-11-29 — — US disclosed
WO-2007109071-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-09-27 — — WO disclosed
US-20070088078-A1 Methods for managing adipocyte fat accumulation WELLGEN, INC. 2007-04-19 — — US disclosed
WO-2007024982-A2 METHODS FOR MANAGING ADIPOCYTE FAT ACCUMULATION WELLGEN, INC. (US) 2007-03-01 — — WO disclosed
US-20070042972-A1 Compositions and methods for optimizing exercise recovery RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2007-02-22 — — US disclosed
WO-2006127996-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2006-11-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042972-A1 Compositions and methods for optimizing exercise recovery GYS1, PYGM, PRDX5 ALDH1A1 3163/4885CYP3A4 144/4885MAPT 4515/4885
US-20070088078-A1 Methods for managing adipocyte fat accumulation FABP4, PLIN5, PLIN3 ALDH1A1 1272/4885CYP3A4 1574/4885MAPT 3872/4885
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions PLIN5, FANCF, COXFA4 ALDH1A1 1794/4885CYP3A4 390/4885MAPT 4329/4885
US-20140039044-A1 Hydroxylated Polymethoxyflavone Compositions PLIN5, FANCF, COXFA4 ALDH1A1 1794/4885CYP3A4 390/4885MAPT 4329/4885
US-20110287106-A1 COGNITIVE IMPAIRMENT AMELIORANT CHAT, ACHE, PSEN1 ALDH1A1 2200/4885CYP3A4 4098/4885MAPT 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.