SCHEMBL683718

SCHEMBL683718

CC1(C)C=Cc2cc3c(C(F)(F)F)c(F)c(=O)[nH]c3cc2N1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 19/20 0.63
PGR P06401 15/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL683713 0.78 AR (1.00) ARPGR
SCHEMBL14409341 0.72 AR (0.64) ARPGR
SCHEMBL19603965 0.67 PGR (0.62) ARPGR
SCHEMBL1770722 0.64 AR (0.55) AR
SCHEMBL1771247 0.64 AR (0.55) ARPGR
SCHEMBL1772458 0.64 GSK3B (0.45)
SCHEMBL10838748 0.63 PGR (0.47) ARPGR
SCHEMBL1772676 0.61 AR (0.61) AR
SCHEMBL1771342 0.61 AR (0.42) AR
SCHEMBL1772197 0.60 AR (0.62) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3357513-B1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2023-10-25 EP disclosed
EP-3527210-B1 COMBINED COMPOSITION COMPRISING A BENZOHETEROCYCLIC COMPOUND AND AN ANDROGEN RECEPTOR PATHWAY MODULATOR AND USES THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2021-06-09 EP disclosed
US-20210113545-A1 Pharmaceutical Composition Comprising a Benzoheterocyclic Compound and Androgen Receptor Pathway Modulator and Application Thereof KANGPU BIOPHARMACEUTICALS LTD (CN) 2021-04-22 US disclosed
US-10933059-B2 Combination, application thereof and treatment method KANGPU BIOPHARMACEUTICALS. LTD. (CN) 2021-03-02 US disclosed
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD KANGPU BIOPHARMACEUTICALS, LTD. (CN) 2019-10-31 US disclosed
EP-3527210-A1 COMPOSITION, APPLICATION THEREOF AND TREATMENT METHOD Kangpu Biopharmaceuticals, Ltd. (CN) 2019-08-21 EP disclosed
EP-3357513-A1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Kangpu Biopharmaceuticals, Ltd. (CN) 2018-08-08 EP disclosed
US-9205102-B2 Method for treatment of castration-resistant prostate cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-12-08 US disclosed
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-06-11 US disclosed
WO-2012170599-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2012-12-13 WO disclosed
US-20070208029-A1 MODULATION OF NEUROGENESIS BY PDE INHIBITION BRAINCELLS, INC. (US) 2007-09-06 US disclosed
US-20070112017-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS BRAINCELLS, INC. (US) 2007-05-17 US disclosed
US-20070112017-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS BRAINCELLS, INC. (US) 2007-05-17 US disclosed
WO-2007053596-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS BRAINCELLS, INC. (US) 2007-05-10 WO disclosed
WO-2007047978-A2 MODULATION OF NEUROGENESIS BY PDE INHIBITION BRAINCELLS, INC. (US) 2007-04-26 WO disclosed
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION BRAINCELLS, INC. (US) 2007-04-05 US disclosed
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION BRAINCELLS, INC. (US) 2007-04-05 US disclosed
WO-2007025177-A2 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 WO disclosed
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 US disclosed
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD CYP21A2, CYP17A1, NR5A1 AR 5/4885PGR 96/4885
US-20210113545-A1 Pharmaceutical Composition Comprising a Benzoheterocyclic Compound and Androgen Receptor Pathway Modulator and Application Thereof AR, NR5A1, CYP17A1 AR 1/4885PGR 186/4885
US-20070112017-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS GABRB2, GAP43, GABRB1 AR 1818/4885PGR 1096/4885
US-10933059-B2 Combination, application thereof and treatment method CYP21A2, CYP17A1, NR5A1 AR 5/4885PGR 96/4885
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION DCX, BDNF, NTRK2 AR 2420/4885PGR 2085/4885
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer IGFBP5, IGFBP2, IGFBP1 AR 7/4885PGR 414/4885
US-20070208029-A1 MODULATION OF NEUROGENESIS BY PDE INHIBITION PDE2A, PDE4A, DCX AR 1853/4885PGR 2094/4885
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION CHRNB2, CHAT, CHRNB4 AR 1207/4885PGR 450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.