Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | XBP1 | P17861 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844881 | 0.90 | CA1 (0.38) | ELANERORCCA1CA2CA12 | |
| SCHEMBL6844871 | 0.81 | MALT1 (0.39) | ACACBRORCCA1CA2CA12 | |
| SCHEMBL6844879 | 0.80 | POLB (0.36) | MAPTPOLBALDH1A1HTTKMT2A | |
| SCHEMBL6844919 | 0.78 | POLB (0.34) | ELANERORCMAPTPOLBALDH1A1 | |
| SCHEMBL14727527 | 0.76 | METAP2 (0.35) | ELANECA1CA12CA7CA14 | |
| SCHEMBL6844858 | 0.73 | TSHR (0.34) | CA2CA12POLBALDH1A1HTT | |
| SCHEMBL6844927 | 0.72 | TARBP2 (0.32) | MAPTALDH1A1 | |
| SCHEMBL6844872 | 0.72 | CA1 (0.36) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6844910 | 0.70 | HTR6 (0.32) | ALDH1A1HSD17B10KMT2AMEN1TSHR | |
| SCHEMBL1648546 | 0.70 | CA1 (0.45) | CA1CA2CA12MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |