SCHEMBL684754

SCHEMBL684754

[C-]#[N+]c1cc(C)c(NC(=O)c2cc(Cn3nnc(C(F)(F)F)n3)nn2-c2ccccc2Cl)c(C(=O)NC(C)(C)C)c1

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
NPC1 O15118 1/20 0.31
HPGD P15428 1/20 0.31
RAB9A P51151 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SLC16A3 O15427 3/20 0.30
SLC16A1 P53985 3/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
IDH1 O75874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685551 0.93 IDH1 (0.32) MEN1KMT2ANPC1RAB9AIDH1
SCHEMBL684763 0.91 SLC16A3 (0.31) SLC16A3SLC16A1
SCHEMBL13085512 0.91 NPC1 (0.35) MEN1KMT2ANPC1HPGDRAB9A
SCHEMBL685472 0.90 DHODH (0.31) SMN1; SMN2
SCHEMBL10151093 0.89 NPC1 (0.35) MEN1KMT2ANPC1HPGDRAB9A
SCHEMBL10076311 0.88 SLC2A1 (0.35) MEN1KMT2ASLC16A3SLC16A1IDH1
SCHEMBL685916 0.87 SMN1; SMN2 (0.31) MEN1KMT2ASMN1; SMN2NPSR1
SCHEMBL10072955 0.86
SCHEMBL13085424 0.85 NPC1 (0.34) MEN1KMT2ANPC1HPGDRAB9A
SCHEMBL10072948 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US disclosed
US-9700049-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-07-11 US disclosed
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT BAYER INTELLECTUAL PROPERTY GMBH 2017-06-08 US disclosed
US-9572342-B2 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biologicalcontrol agent BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-02-21 US disclosed
US-9414595-B2 Use of anthranilic acid diamide derivatives for pest control in transgenic crops BAYER CROPSCIENCE AG (DE) 2016-08-16 US disclosed
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-05-12 US disclosed
US-9265255-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-02-23 US disclosed
US-20160037775-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-11 US disclosed
US-9198424-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 US disclosed
US-20140329676-A1 USE OF ANTHRANILIC ACID DIAMIDE DERIVATIVES FOR PEST CONTROL IN TRANSGENIC CROPS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2014-11-06 US disclosed
US-8658570-B2 Use of anthranilamide derivatives for controlling insects and spider mites by drenching, soil mixing, furrow treatment, drip application, soil, stem or flower injection, in hydroponic systems, by planting hole treatment or dip application, floating or seedbox application or by treating seed, and also for enhancing the stress tolerance of plants to abiotic stress BAYER CROPSCIENCE AG (DE) 2014-02-25 US disclosed
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 US disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010073-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 MEN1 1806/4885KMT2A 388/4885NPC1 3763/4885
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS CDY1; CDY1B, DHX9, DHX29 MEN1 3288/4885KMT2A 2308/4885NPC1 4858/4885
US-20140329676-A1 USE OF ANTHRANILIC ACID DIAMIDE DERIVATIVES FOR PEST CONTROL IN TRANSGENIC CROPS AADAC, DDT, QDPR MEN1 2959/4885KMT2A 198/4885NPC1 4219/4885
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES AADAC, ANTXR2, CYP51A1 MEN1 1806/4885KMT2A 388/4885NPC1 3763/4885
US-20170265470-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 MEN1 1806/4885KMT2A 388/4885NPC1 3763/4885
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT CYC1, TPD52L2, DBF4 MEN1 1314/4885KMT2A 1794/4885NPC1 4549/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 MEN1 3346/4885KMT2A 2896/4885NPC1 843/4885
US-20160037775-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES ACHE, ACAT1, ACAT2 MEN1 3346/4885KMT2A 2896/4885NPC1 843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.