Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.47 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878144 | 1.00 | HSD11B1 (0.62) | HSD11B1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL4821062 | 0.90 | KMT2A (0.68) | HSD11B1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL3136872 | 0.90 | KMT2A (0.68) | HSD11B1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1284284 | 0.82 | RAB9A (0.60) | LMNAKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL20585389 | 0.82 | HSD11B1 (0.64) | HSD11B1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL21235162 | 0.82 | TYR (0.61) | HSD11B1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1284286 | 0.82 | RAB9A (0.60) | LMNAKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL27628008 | 0.82 | HSD11B1 (0.64) | HSD11B1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL10001179 | 0.81 | CYP1A2 (0.68) | LMNAKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL23866749 | 0.81 | LMNA (0.58) | LMNAKMT2AMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | disclosed |
| WO-2020146636-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE | DREXEL UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
| US-6787657-B2 | INTERMEDIATES FOR DRUGS, AGRICULTURAL CHEMICALS | TOSOH CORPORATION (JP) | 2004-09-07 | — | — | US | disclosed |
| US-20010020106-A1 | Optically active epoxypropionate derivative, intermediate thereof and processes for their production | TOSOH CORPORATION (JP) | 2001-09-06 | — | — | US | disclosed |
| EP-1127885-A2 | Optically active epoxypropionate derivatives, intermediates, and processes for their production | Tosoh Corporation (JP) | 2001-08-29 | — | — | EP | disclosed |
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | SQOR, QSOX1, KEAP1 | HSD11B1 287/4885LMNA 2504/4885KMT2A 677/4885 |
| US-20010020106-A1 | Optically active epoxypropionate derivative, intermediate thereof and processes for their production | CYP11B1, POR, CYP11B2 | HSD11B1 29/4885LMNA 2220/4885KMT2A 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.