Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328654 | 0.91 | MMP3 (0.36) | KMT2AALDH1A1 | |
| SCHEMBL6851665 | 0.87 | P2RX7 (0.41) | — | |
| SCHEMBL6850244 | 0.87 | EDNRA (0.39) | DAGLAHTTL3MBTL1 | |
| SCHEMBL328643 | 0.86 | KMT2A (0.35) | DAGLAPGRKMT2APOLBALDH1A1 | |
| SCHEMBL328661 | 0.82 | KMT2A (0.38) | DAGLAKMT2APOLBHPGDALDH1A1 | |
| SCHEMBL328414 | 0.81 | DAGLA (0.37) | DAGLAPGRKMT2APOLBHPGD | |
| SCHEMBL328548 | 0.80 | DAGLA (0.37) | DAGLAPGRKMT2APOLBHPGD | |
| SCHEMBL328652 | 0.79 | P2RX7 (0.40) | — | |
| SCHEMBL328544 | 0.78 | DAGLA (0.35) | DAGLAKMT2APOLBHPGDALDH1A1 | |
| SCHEMBL328545 | 0.78 | HDAC6 (0.47) | KMT2AHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |