Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328652 | 0.91 | P2RX7 (0.40) | P2RX7FLT3SCN9AROCK1ROCK2 | |
| SCHEMBL6851659 | 0.87 | CSF1R (0.33) | — | |
| SCHEMBL6850244 | 0.85 | EDNRA (0.39) | ROCK1ROCK2 | |
| SCHEMBL328661 | 0.81 | KMT2A (0.38) | — | |
| SCHEMBL328414 | 0.80 | DAGLA (0.37) | — | |
| SCHEMBL328548 | 0.80 | DAGLA (0.37) | — | |
| SCHEMBL328658 | 0.79 | HSP90AA1 (0.41) | — | |
| SCHEMBL328654 | 0.79 | MMP3 (0.36) | — | |
| SCHEMBL328659 | 0.78 | RORC (0.40) | — | |
| SCHEMBL328544 | 0.77 | DAGLA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |