Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 7/20 | 0.40 |
| ▸ | TACR3 | P29371 | 6/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848935 | 0.88 | SLC2A1 (0.44) | PDE10ATACR2TACR3FAAHPIK3CD | |
| SCHEMBL6853013 | 0.86 | HRH3 (0.48) | PDE10AFAAHPIK3CDBACE1ALDH1A1 | |
| SCHEMBL6848678 | 0.83 | TACR2 (0.53) | PDE10ATACR2TACR3FAAHPIK3CD | |
| SCHEMBL6854970 | 0.82 | KMT2A (0.50) | PDE10AFAAHALDH1A1NCF1KDM4E | |
| SCHEMBL6853072 | 0.79 | ADORA2A (0.53) | TACR3FAAHALDH1A1NCF1MAPT | |
| SCHEMBL5908682 | 0.78 | FAAH (0.42) | PDE10AFAAHPIK3CDPIK3CGBACE1 | |
| SCHEMBL6853077 | 0.78 | HTR2B (0.49) | FAAHALDH1A1KDM4EHTT | |
| SCHEMBL5442168 | 0.78 | PDE10A (0.43) | PDE10AFAAHPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6853643 | 0.77 | TSHR (0.55) | ALDH1A1KDM4EHTT | |
| SCHEMBL6853186 | 0.77 | LDHA (0.49) | PDE10ATACR3FAAHPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |