Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853643 | 0.88 | TSHR (0.55) | DRD4DRD2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6854970 | 0.81 | KMT2A (0.50) | DRD4DRD2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6853013 | 0.80 | HRH3 (0.48) | ALDH1A1KDM4EKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL6853077 | 0.77 | HTR2B (0.49) | DRD4DRD2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6848678 | 0.77 | TACR2 (0.53) | LMNAHTTNPSR1 | |
| SCHEMBL6848935 | 0.77 | SLC2A1 (0.44) | ALDH1A1KDM4EHTT | |
| SCHEMBL5908682 | 0.77 | FAAH (0.42) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL5442168 | 0.77 | PDE10A (0.43) | ALDH1A1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL4753320 | 0.76 | HTR7 (0.65) | DRD4DRD2ALDH1A1KDM4EKMT2A | |
| SCHEMBL4254056 | 0.76 | DRD4 (0.56) | DRD4DRD2ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |