Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980872 | 0.78 | TRPA1 (0.36) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL484284 | 0.74 | — | — | |
| SCHEMBL8782174 | 0.74 | — | — | |
| SCHEMBL7167505 | 0.71 | TRPA1 (0.31) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL8469463 | 0.70 | — | — | |
| SCHEMBL5251799 | 0.69 | — | — | |
| SCHEMBL6129983 | 0.65 | RECQL (0.39) | HPGD | |
| SCHEMBL9860953 | 0.65 | CA12 (0.31) | ALDH1A1 | |
| SCHEMBL62283 | 0.64 | — | — | |
| SCHEMBL131938 | 0.64 | RECQL (0.37) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020015612-A1 | FUCOSYLATED CHONDROITIN SULFATE OLIGOSACCHARIDE, PREPARATION METHOD THEREFOR, COMPOSITION THEREOF AND USE THEREOF | 北京大学 | 2020-01-23 | — | — | WO | claimed |
| US-10759822-B2 | Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2020-09-01 | — | — | US | disclosed |
| US-20190077821-A1 | Brain-Targeting Prodrug for AMPA Receptor Synergist, and Pharmaceutical Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-03-14 | — | — | US | disclosed |
| EP-3444240-A1 | BRAIN-TARGETING PRODRUG FOR AMPA RECEPTOR SYNERGIST, AND PHARMACEUTICAL APPLICATIONS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2019-02-20 | — | — | EP | disclosed |
| US-6818117-B2 | ELECTROLYSIS OXIDATION | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-11-16 | — | — | US | disclosed |
| US-6730493-B1 | RECOGNIZING AND DETERMINING THE EXTENT OF THE DAMAGE TO HAIR OR WOOL, FOR EXAMPLE; INCLUDES ENZYMATIC AND/OR CHEMICAL TREATMENT FOR PROTEOLYTIC OR HYDROLYTIC DEGRADATION OF THE SAMPLE, PHYSICAL MEASUREMENT OF TURBIDITY; KITS | WELLA AKTIENGESELLSCHAFT (DE) | 2004-05-04 | — | — | US | disclosed |
| US-20030024823-A1 | Electrochemically directed self-assembly of monolayers on metal | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-02-06 | — | — | US | disclosed |
| WO-2002072282-A1 | ELECTROCHEMICALLY DIRECTED SELF-ASSEMBLY OF MONOLAYERS ON METAL | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2002-09-19 | — | — | WO | disclosed |
| EP-0109955-B1 | RUBBER/METAL COMPOSITES | MONSANTO EUROPE S.A./N.V. (BE) | 1988-01-20 | — | — | EP | disclosed |
| US-4704334-A | ORGANIC THIOSULFATE ADHESION PROMOTERS | MONSANTO EUROPE, S.A. (BE) | 1987-11-03 | — | — | US | disclosed |
| US-4532080-A | Cobalt or nickel salt of organic thiosulfate ester | MONSANTO EUROPE, S.A. (BE) | 1985-07-30 | — | — | US | disclosed |
| EP-0109955-A2 | Rubber/metal composites | MONSANTO EUROPE S.A./N.V. (BE) | 1984-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759822-B2 | Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof | GRM3, GRM1, GRM2 | ALOX5 2107/4885TRPA1 1494/4885ALDH1A1 933/4885 |
| US-20190077821-A1 | Brain-Targeting Prodrug for AMPA Receptor Synergist, and Pharmaceutical Applications Thereof | GRM3, GRM1, GRM2 | ALOX5 2107/4885TRPA1 1494/4885ALDH1A1 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.