SCHEMBL689466

SCHEMBL689466

C[Si](C)(C)O[Si](C)(CCCNc1nc(Cl)nc(Cl)n1)O[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
LMNA P02545 1/20 0.40
NR1I2 O75469 1/20 0.35
AHR P35869 1/20 0.35
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
CA14 Q9ULX7 1/20 0.33
MAPT P10636 1/20 0.33
PKM P14618 1/20 0.32
RAD52 P43351 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15106918 0.82 KMT2A (0.45) KMT2ALMNANR1I2AHRCA12
SCHEMBL13558679 0.75 KMT2A (0.53) KMT2ALMNANR1I2AHRCA12
SCHEMBL20053796 0.75 KMT2A (0.58) KMT2ALMNANR1I2AHRCA12
SCHEMBL3128644 0.75 ALDH1A1 (0.32) ALDH1A1
SCHEMBL140123 0.73 KMT2A (0.61) KMT2ALMNANR1I2AHRCA12
SCHEMBL16628595 0.73 KMT2A (0.46) KMT2ALMNANR1I2AHRCA12
SCHEMBL987508 0.72 KMT2A (0.66) KMT2ALMNANR1I2AHRCA1
SCHEMBL20511066 0.72 KCNH3 (0.51) KMT2ALMNANR1I2AHRMAPT
SCHEMBL19465170 0.71 KMT2A (0.48) KMT2ALMNANR1I2AHRCA12
SCHEMBL11083082 0.71 LMNA (0.56) KMT2ALMNANR1I2AHRCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170135933-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING PHOTOSENSITIVE 1,3,5-TRIAZINE COMPOUNDS, DIBENZOYLMETHANE COMPOUNDS AND SILICEOUS S-TRIAZINES SUBSTITUTED WITH TWO AMINOBENZOATE OR AMINOBENZAMIDE GROUPS L'OREAL (FR) 2017-05-18 US disclosed
US-9526924-B2 Composition comprising a screening agent of the lipophilic 2-hydroxybenzophenone type and a silicon-compromising s-triazine substituted by at least two alkylaminobenzoate groups L'OREAL (FR) 2016-12-27 US disclosed
US-8999299-B2 Photoprotective cosmetic compositions comprising silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups and non-silicon-containing lipophilic triazine compound UV-screening agents L'OREAL (FR) 2015-04-07 US disclosed
US-8747816-B2 UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups L'OREAL (FR) 2014-06-10 US disclosed
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP disclosed
US-20120201767-A1 COMPOSITION COMPRISING A SCREENING AGENT OF THE LIPOPHILIC 2-HYDROXYBENZOPHENONE TYPE AND A SILICON-COMPRISING S-TRIAZINE SUBSTITUTED BY AT LEAST TWO ALKYLAMINOBENZOATE GROUPS L'OREAL (FR) 2012-08-09 US disclosed
EP-1927343-B1 Photoprotective composition containing a photosensitive 1,3,5-triazine derivative, a dibenzoylmethane derivative and a siliceous s-triazine substituted with two aminobenzoate or aminobenzamide groups OREAL (FR) 2012-02-29 EP disclosed
EP-1927345-B1 Cosmetic composition containing the combination of a silicon-containing s-triazine substituted with two aminobenzoate or aminobenzamide groups and a silicon-free lipophilic triazine UV-screening agent OREAL (FR) 2012-01-18 EP disclosed
EP-1891079-B1 PHOTOSTABILIZATION OF A DIBENZOYLMETHANE BY A SILICON- CONTAINING S-TRIAZINE SUBSTITUTED WITH TWO AMINOBENZOATE OR AMINOBENZAMIDE GROUPS; PHOTOPROTECTIVE COMPOSITIONS. NOVEL SILICON-CONTAINING S-TRIAZINE COMPOUNDS OREAL (FR) 2010-10-27 EP disclosed
US-20100003207-A1 Photoprotective compositions comprising photosensitive 1,3,5-triazine compounds, dibenzoylmethane compounds and siliceous s-triazines substituted with two aminobenzoate or aminobenzamide groups L'OREAL (FR) 2010-01-07 US disclosed
WO-2009074409-A1 S-TRIAZINE COMPOUNDS CONTAINING ONE AMINOSILOXANE GROUP AND TWO PARTICULAR PARA-AMINOBENZALMALONATE GROUPS; COSMETIC COMPOSITIONS CONTAINING SAID DERIVATIVES; USES OF SAID S-TRIAZINE DERIVATIVES L'OREAL (FR) 2009-06-18 WO disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20080145324-A1 UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups L'OREAL (FR) 2008-06-19 US disclosed
US-20080138303-A1 Photoprotective cosmetic compositions comprising silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups and non-silicon-containing lipophilic triazine compound UV-screening agents L'OREAL (FR) 2008-06-12 US disclosed
EP-1927343-A1 Photoprotective composition containing a photosensitive 1,3,5-triazine derivative, a dibenzoylmethane derivative and a siliceous s-triazine and substituted with two aminobenzoate or aminobenzamide groups L'Oréal (FR) 2008-06-04 EP disclosed
EP-1927345-A1 Cosmetic composition containing the combination of a silicon-containing s-triazine substituted with two aminobenzoate or aminobenzamide groups and a non-silicon-containing lipophilic triazine uv-screening agent L'Oréal (FR) 2008-06-04 EP disclosed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US disclosed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080145324-A1 UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups TST, TYR, DDT KMT2A 672/4885LMNA 2847/4885NR1I2 3126/4885
US-20120201767-A1 COMPOSITION COMPRISING A SCREENING AGENT OF THE LIPOPHILIC 2-HYDROXYBENZOPHENONE TYPE AND A SILICON-COMPRISING S-TRIAZINE SUBSTITUTED BY AT LEAST TWO ALKYLAMINOBENZOATE GROUPS STS, TST, ARSA KMT2A 1431/4885LMNA 2221/4885NR1I2 1209/4885
US-20100003207-A1 Photoprotective compositions comprising photosensitive 1,3,5-triazine compounds, dibenzoylmethane compounds and siliceous s-triazines substituted with two aminobenzoate or aminobenzamide groups CUTA, TST, DSG1 KMT2A 731/4885LMNA 2246/4885NR1I2 3374/4885
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof TYR, AAAS, ALAD KMT2A 1215/4885LMNA 3221/4885NR1I2 2500/4885
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF TYR, AAAS, ALAD KMT2A 1027/4885LMNA 3342/4885NR1I2 2470/4885
US-20170135933-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING PHOTOSENSITIVE 1,3,5-TRIAZINE COMPOUNDS, DIBENZOYLMETHANE COMPOUNDS AND SILICEOUS S-TRIAZINES SUBSTITUTED WITH TWO AMINOBENZOATE OR AMINOBENZAMIDE GROUPS CUTA, TST, DSG1 KMT2A 731/4885LMNA 2246/4885NR1I2 3374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.