Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29851622 | 1.00 | CES2 (0.53) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL27373888 | 0.82 | NPC1 (0.58) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL22561759 | 0.81 | KMT2A (0.45) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL7723773 | 0.78 | CES2 (0.52) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL7723776 | 0.78 | CES2 (0.52) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL28471256 | 0.78 | NPC1 (0.54) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL979427 | 0.77 | CES1 (0.46) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL14925777 | 0.77 | NPC1 (0.52) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL30924789 | 0.77 | HPGD (0.59) | CES2CES1HPGDKMT2AKDM4E | |
| SCHEMBL7913771 | 0.77 | HPGD (0.59) | CES2CES1HPGDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368351-A | Preparation method and application of polysubstituted oxazole compound | 广东工业大学 | 2022-11-22 | — | — | CN | disclosed |
| US-10196413-B2 | Chiral dihydrobenzoazaphosphole ligands and synthesis thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-02-05 | — | — | US | disclosed |
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| WO-2018106621-A1 | NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-14 | — | — | WO | disclosed |
| US-20180155377-A1 | NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-07 | — | — | US | disclosed |
| US-20180155377-A1 | NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-07 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| US-20170291885-A1 | METHOD FOR PREPARING ENAMIDE COMPOUND AND RUTHENIUM COMPLEX CATALYST USED THEREIN | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2017-10-12 | — | — | US | disclosed |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2009-06-11 | — | — | US | disclosed |
| CN-100482671-C | Chiral monophosphorous ligand, synthetic method and its use | SHANGHAI INST ORGANIC CHEM (CN) | 2009-04-29 | — | — | CN | disclosed |
| WO-2007115185-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | SEPRACOR INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| CN-1309728-C | Chiral organic, inorganic polymer assembled catalyst, synthesis method and use | SHANGHAI INST ORGANIC CHEM (CN) | 2007-04-11 | — | — | CN | disclosed |
| CN-1616470-A | Chiral monophosphorous ligand, synthetic method and its use | SHANGHAI INST ORGANIC CHEM (CN) | 2005-05-18 | — | — | CN | disclosed |
| CN-1597114-A | Chiral organic, inorganic polymer assembled catalyst, synthesis method and use | SHANGHAI INST ORGANIC CHEM (CN) | 2005-03-23 | — | — | CN | disclosed |
| US-6794525-B2 | USING CHIRAL DIPHOSPHINES AS OPTICALLY ACTIVE LIGANDS FOR THE PREPARATION OF DIPHOSPHINO-METAL COMPLEXES | PPG-SIPSY (FR) | 2004-09-21 | — | — | US | disclosed |
| US-20030195369-A1 | Optically active chiral diphosphine ligands | PPG-SIPSY (FR) | 2003-10-16 | — | — | US | disclosed |
| US-6399787-B1 | TRANSITION METAL COMPLEX | PENN STATE RESEARCH FOUNDATION | 2002-06-04 | — | — | US | disclosed |
| WO-1999059721-A1 | CATALYTIC ASYMMETRIC HYDROGENATION, HYDROFORMYLATION, AND HYDROVINYLATION VIA TRANSITION METAL CATALYSTS WITH PHOSPHINES AND PHOSPHITES | THE PENN STATE RESEARCH FOUNDATION (US) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | PNMT, ALKBH5, ALKBH2 | CES2 275/4885CES1 1643/4885HPGD 582/4885 |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH2, ALKBH5 | CES2 281/4885CES1 1627/4885HPGD 630/4885 |
| US-20180155377-A1 | NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | FDPS, GNPAT, PPIP5K2 | CES2 3710/4885CES1 4257/4885HPGD 2653/4885 |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CES2 275/4885CES1 1643/4885HPGD 582/4885 |
| US-10196413-B2 | Chiral dihydrobenzoazaphosphole ligands and synthesis thereof | DHODH, FDPS, GNPAT | CES2 3276/4885CES1 4030/4885HPGD 2238/4885 |
| US-20030195369-A1 | Optically active chiral diphosphine ligands | NR4A1, GPR4, HTR4 | CES2 2542/4885CES1 1787/4885HPGD 3744/4885 |
| US-20170291885-A1 | METHOD FOR PREPARING ENAMIDE COMPOUND AND RUTHENIUM COMPLEX CATALYST USED THEREIN | ENY2, ENO1, IDH1 | CES2 1154/4885CES1 4116/4885HPGD 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.