Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | BID | P55957 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.45 |
| ▸ | PPARD | Q03181 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959902 | 0.90 | PPARG (0.53) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL6960149 | 0.85 | CCR2 (0.70) | BCL2BIDMCL1CCR2NOD2 | |
| SCHEMBL6955317 | 0.82 | CCR2 (0.73) | BCL2BIDMCL1CCR2NOD2 | |
| SCHEMBL3363385 | 0.78 | NOD2 (0.46) | BCL2BIDMCL1CCR2NOD2 | |
| SCHEMBL6965196 | 0.78 | NOD2 (0.60) | BCL2BIDMCL1CCR2NOD2 | |
| SCHEMBL6966440 | 0.77 | CCR2 (0.45) | BCL2BIDMCL1CCR2NOD2 | |
| SCHEMBL6964749 | 0.77 | CCR2 (0.52) | CCR2NOD1PPARGPPARDPPARA | |
| SCHEMBL3364943 | 0.73 | PPARG (0.49) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL28246138 | 0.73 | HTR6 (0.52) | CCR2NOD2NOD1MAPTHTR6 | |
| SCHEMBL6959898 | 0.72 | ACLY (0.61) | BCL2BIDMCL1CCR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001935-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | claimed |