Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.70 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964749 | 0.86 | CCR2 (0.52) | CCR2NOD1ACLYPPARG | |
| SCHEMBL6955774 | 0.85 | BCL2 (0.50) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6959828 | 0.82 | CCR2 (1.00) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL3363385 | 0.81 | NOD2 (0.46) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6966440 | 0.80 | CCR2 (0.45) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6963990 | 0.78 | CCR2 (0.74) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6959902 | 0.75 | PPARG (0.53) | ACLYALDH1A1PPARGKMT2A | |
| SCHEMBL9239991 | 0.72 | CCR2 (0.67) | CCR2LMNAMAPT | |
| SCHEMBL3364943 | 0.71 | PPARG (0.49) | ACLYPPARGKMT2A | |
| SCHEMBL28246138 | 0.70 | HTR6 (0.52) | CCR2NOD1NOD2CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001935-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | claimed |