Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964951 | 0.88 | ALDH1A1 (0.32) | KDM4EALDH1A1LMNA | |
| SCHEMBL6972629 | 0.88 | AGTR1 (0.37) | AGTR1AGTR2CCR5KDM4EALDH1A1 | |
| SCHEMBL6962314 | 0.86 | L3MBTL1 (0.36) | AGTR2CCR5ALDH1A1LMNA | |
| SCHEMBL6964071 | 0.86 | ALDH1A1 (0.35) | AGTR1AGTR2CCR5KDM4EALDH1A1 | |
| SCHEMBL6962626 | 0.86 | AGTR1 (0.34) | AGTR1AGTR2CCR5ALDH1A1TDP1 | |
| SCHEMBL6967867 | 0.85 | CCR2 (0.40) | KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL7081352 | 0.84 | TDP1 (0.31) | TDP1ENPP2 | |
| SCHEMBL6957642 | 0.83 | ALDH1A1 (0.34) | KDM4EALDH1A1LMNA | |
| SCHEMBL7084635 | 0.82 | ADRA1D (0.35) | KDM4EALDH1A1 | |
| SCHEMBL6973396 | 0.81 | PIM1 (0.34) | TDP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | claimed |
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |