Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986889 | 0.85 | L3MBTL1 (0.40) | KMT2ALMNAMAPTHRH3ALDH1A1 | |
| SCHEMBL6987568 | 0.81 | BMPR1B (0.35) | LMNAMAPTBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL6988129 | 0.80 | TSHR (0.40) | KMT2AMAPTMAPK1SMN1; SMN2POLB | |
| SCHEMBL6988697 | 0.79 | NR3C2 (0.43) | — | |
| SCHEMBL6981881 | 0.78 | PDE10A (0.43) | LMNAPOLBALDH1A1 | |
| SCHEMBL6984622 | 0.74 | AGTR2 (0.39) | KMT2ALMNABMPR1BBMPR1ATGFBR1 | |
| SCHEMBL6987158 | 0.73 | MEN1 (0.46) | KMT2ALMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL6986823 | 0.69 | MGLL (0.60) | LMNASMN1; SMN2BRD4NPC1ALDH1A1 | |
| SCHEMBL6987595 | 0.67 | TDP1 (0.42) | KMT2ASMN1; SMN2POLBALDH1A1TDP1 | |
| SCHEMBL6981026 | 0.67 | AGTR2 (0.40) | KMT2ALMNAMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |