Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069660 | 1.00 | ALOX5 (0.45) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL27483589 | 0.88 | CHRM3 (0.46) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL27388408 | 0.88 | CHRM3 (0.46) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL1063230 | 0.87 | LMNA (0.41) | LMNAMEN1MAPTHTR1EKMT2A | |
| SCHEMBL6217943 | 0.86 | PTGS1 (0.36) | ALOX5HDAC6TSHRPTGS1PTGS2 | |
| SCHEMBL10006210 | 0.84 | NPC1 (0.46) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL27368748 | 0.84 | BDKRB2 (0.48) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL27361339 | 0.84 | BDKRB2 (0.48) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL8634916 | 0.83 | CHRM3 (0.47) | ALOX5HDAC6LMNAMEN1MAPT | |
| SCHEMBL17846888 | 0.81 | HTR1E (0.47) | ALOX5HDAC6LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799829-B1 | Process for the preparation of enantiomerically pure cycloalkanoindole-, azaindole- and pyrimido [1,2a] indole carboxylic acids and their activated derivatives | BAYER AG (DE) | 2003-07-30 | — | — | EP | claimed |
| US-8987256-B2 | Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-20120172448-A1 | Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-07-05 | — | — | US | disclosed |
| US-6194424-B1 | ANTICHOLESTEROL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-02-27 | — | — | US | disclosed |
| US-6114341-A | TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| US-5952498-A | SYNTHESIZING THE CHEMICAL INTERMEDIATES FOR ANTIATHEROSCLEROTICALLY ACTIVE DRUG | BAYER AKTIENGESELLSCHAFT (DE) | 1999-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172448-A1 | Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof | PC, ACACA, PCCA | ALOX5 782/4885HDAC6 1573/4885LMNA 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.