Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823359 | 0.84 | ALDH1A1 (0.45) | ALDH1A1NPSR1LMNACYP3A4CYP2D6 | |
| SCHEMBL7027251 | 0.83 | MEN1 (0.45) | ALDH1A1GAARAB9ASMN1; SMN2MAPT | |
| SCHEMBL8093014 | 0.83 | TSHR (0.49) | ALDH1A1MAPTTDP1 | |
| SCHEMBL7023148 | 0.81 | HTR1A (0.43) | ALDH1A1RAB9ASMN1; SMN2MAPTTDP1 | |
| SCHEMBL4871015 | 0.79 | TSHR (0.40) | ALDH1A1RAB9ASMN1; SMN2MAPTTDP1 | |
| SCHEMBL14268974 | 0.79 | TDP1 (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19RAB9A | |
| SCHEMBL14268976 | 0.79 | HTR1A (0.44) | ALDH1A1RAB9ASMN1; SMN2MAPTTDP1 | |
| SCHEMBL4867949 | 0.79 | CYP2E1 (0.43) | ALDH1A1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4862725 | 0.78 | HTR1A (0.43) | ALDH1A1TDP1HTR1A | |
| SCHEMBL13851862 | 0.78 | TDP1 (0.42) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016669-B1 | New derivatives of erythromycin, process for making them as well as their use as medicaments | AVENTIS PHARMA SA (FR) | 2003-02-19 | — | — | EP | disclosed |
| US-6455505-B2 | 11,12-DIDEOXY-3-DE((2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L -RIBOHEXOPYRANOSYL)OXY) 6-0-METHYL 3-OXO-12,11-(OXYCARBONYL) ((4-(4-(4-AMINOPHENYL)-1H-IMIDAZOL-1-YL)-BUTYL)IMINO))-ERYTHROMYCIN; GRAMPOSITIVE BACTERIA, ESP. STAPHYLOCCUS | HOECHST MARION ROUSSEL (FR) | 2002-09-24 | — | — | US | disclosed |
| US-6407257-B1 | ANTIBIOTICS | AVENTIS PHARMA S.A. (FR) | 2002-06-18 | — | — | US | disclosed |
| US-20020028781-A1 | New derivatives of erythromycin, their preparation process and their use as medicaments | HOECHST MARION ROUSSEL | 2002-03-07 | — | — | US | disclosed |
| US-20020013281-A1 | DERIVATIVES ...USE AS MEDICAMENTS | HOECHST MARION ROUSSEL (FR) | 2002-01-31 | — | — | US | disclosed |
| EP-1016669-A1 | New derivatives of erythromycin, process for making them as well as their use as medicaments | HOECHST MARION ROUSSEL (FR) | 2000-07-05 | — | — | EP | disclosed |
| WO-2000027857-A2 | NOVEL ERYTHROMYCIN DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013281-A1 | DERIVATIVES ...USE AS MEDICAMENTS | FPR1, XDH, ABCB11 | ALDH1A1 446/4885NPSR1 1756/4885LMNA 3283/4885 |
| US-20020028781-A1 | New derivatives of erythromycin, their preparation process and their use as medicaments | MRPL21, CYP51A1, EEF1A1 | ALDH1A1 3315/4885NPSR1 2587/4885LMNA 1480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.