SCHEMBL70366

SCHEMBL70366

CC(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.60
GAA P10253 1/20 0.60
KCNK3 O14649 2/20 0.49
KCNK9 Q9NPC2 2/20 0.49
PTGS1 P23219 1/20 0.49
CTNNB1 P35222 2/20 0.49
WNT3A P56704 2/20 0.49
CNR2 P34972 2/20 0.47
F2R P25116 1/20 0.47
TAS2R14 Q9NYV8 1/20 0.46
PTPRC P08575 1/20 0.45
AKR1C3 P42330 1/20 0.45
AKR1C2 P52895 1/20 0.45
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
PDK1 Q15118 1/20 0.45
PDK2 Q15119 1/20 0.45
PDK3 Q15120 1/20 0.45
PDK4 Q16654 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29579976 1.00 LMNA (0.60) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL23363566 0.98 LMNA (0.58) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL2094617 0.85 PDK2 (0.47) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL746794 0.82 LMNA (0.64) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL14127342 0.82 LMNA (0.53) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL28634751 0.82 LMNA (0.64) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL12327907 0.82 TAS2R14 (0.54) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL2001643 0.82 LMNA (0.46) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL17674663 0.82 PDK2 (0.45) LMNAGAAKCNK3KCNK9CTNNB1
SCHEMBL24436843 0.82 PDK2 (0.49) LMNAGAAPDK1PDK2PDK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 410 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115109759-B Carbonyl reductase LsCR mutant, engineering bacterium and application thereof in preparation of chiral alcohol by asymmetric reduction of carbonyl compound 浙江工业大学 2024-05-03 CN claimed
CN-117867555-A Fluorine-doped carbon quantum dot catalyst for reducing methane by high-efficiency electrocatalytic carbon dioxide, and preparation method and application thereof 上海大学 2024-04-12 CN claimed
CN-116970580-A Short-chain dehydrogenase mutant derived from Raffina and application of short-chain dehydrogenase mutant in catalyzing aryl ketone to prepare chiral alcohol 浙江工业大学 2023-10-31 CN claimed
CN-115109759-A Carbonyl reductase LsCR mutant, engineering bacteria and application in preparation of chiral alcohol by asymmetrically reducing carbonyl compound 浙江工业大学 2022-09-27 CN claimed
CN-112063532-B Geotrichum linum and application thereof in preparation of (S) -1- (2-trifluoromethylphenyl) ethanol 浙江工业大学 2022-05-24 CN claimed
CN-112063532-A Geotrichum linum and application thereof in preparation of (S) -1- (2-trifluoromethylphenyl) ethanol 浙江工业大学 2020-12-11 CN claimed
CN-109810573-A Inorganic nano material prints ink and its preparation method and application TCL集团股份有限公司 2019-05-28 CN claimed
EP-3196183-B1 METHOD FOR PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE TORAY FINECHEMICALS CO LTD (JP) 2019-05-01 EP claimed
US-9783476-B2 Method of producing 2′-trifluoromethyl group-substituted aromatic ketone TORAY FINE CHEMICALS CO., LTD. (JP) 2017-10-10 US claimed
EP-3196183-A1 METHOD FOR PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE Toray Fine Chemicals Co., Ltd. (JP) 2017-07-26 EP claimed
US-20170088499-A1 METHOD OF PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE TORAY FINE CHEMICALS CO., LTD. (JP) 2017-03-30 US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
WO-2010138807-A1 FLUORINATED SILYLETHYNYL PENTACENE COMPOUNDS AND COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 3M INNOVATIVE PROPERTIES COMPANY (US) 2010-12-02 WO claimed
CN-1409697-A Process for production of trifluoromethylacetophenones BAYER AG (DE) 2003-04-09 CN claimed
US-20260085046-A1 Dual Function Compounds For NADPH Oxidase Inhibition And Histone Deacetylase Inhibition TAIWANJ PHARMACEUTICALS CO LTD (TW) 2026-03-26 US disclosed
US-12435078-B2 Pyridazinones and methods of use thereof GFB (ABC), LLC (US) 2025-10-07 US disclosed
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-07-03 US disclosed
US-4209621-A TRANQUILIZERS AMERICAN CYANAMID COMPANY (US) 1980-06-24 US disclosed
US-4178449-A Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines AMERICAN CYANAMID COMPANY (US) 1979-12-11 US disclosed
US-4136019-A ORGANIC TRIFLUORO COMPOUND AS SELECTIVITY AGENT, FATTY ACID COLLECTOR UNITED STATES BORAX & CHEMICAL CORP. (US) 1979-01-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260085046-A1 Dual Function Compounds For NADPH Oxidase Inhibition And Histone Deacetylase Inhibition NOX1, NOX4, CYBB LMNA 3667/4885GAA 1455/4885KCNK3 3402/4885
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC LMNA 1687/4885GAA 78/4885KCNK3 4200/4885
US-12435078-B2 Pyridazinones and methods of use thereof PDXK, ATP6V1B1, REN LMNA 715/4885GAA 928/4885KCNK3 747/4885
US-20170088499-A1 METHOD OF PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE GRIK4, GRIK2, CYP4F12 LMNA 3695/4885GAA 299/4885KCNK3 241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.