Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR known ✓ | P43119 | 15/20 | 0.71 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.71 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.71 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.71 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050802 | 0.90 | PTGIR (0.87) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL7050827 | 0.89 | PTGIR (0.91) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL7050841 | 0.87 | PTGIR (0.69) | PTGIRPTGDRPTGER3PTGER1 | |
| SCHEMBL7052341 | 0.85 | PTGIR (0.81) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL7047631 | 0.85 | PTGIR (0.74) | PTGIRPTGDRPTGER3PTGER1 | |
| SCHEMBL7051546 | 0.84 | PTGIR (0.64) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL7778677 | 0.83 | PTGIR (1.00) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL29760759 | 0.83 | PTGIR (1.00) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL6612986 | 0.83 | PTGIR (1.00) | PTGIRPTGDRPTGER3PTGER1PTGER4 | |
| SCHEMBL6612991 | 0.83 | PTGIR (1.00) | PTGIRPTGDRPTGER3PTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042277-B1 | NAPHTHALENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-04-23 | — | — | EP | claimed |
| EP-1042277-A1 | NAPHTHALENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-11 | — | — | EP | claimed |
| WO-1999032435-A1 | NAPHTHALENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-01 | — | — | WO | claimed |