Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNB4 | O00305 | 5/20 | 0.62 |
| ▸ | CACNA1A | O00555 | 5/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.62 |
| ▸ | CACNG3 | O60359 | 5/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.62 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.62 |
| ▸ | CACNB3 | P54284 | 5/20 | 0.62 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.62 |
| ▸ | CACNG7 | P62955 | 5/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.62 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.62 |
| ▸ | CACNG1 | Q06432 | 5/20 | 0.62 |
| ▸ | CACNB2 | Q08289 | 5/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.62 |
| ▸ | CACNA1E | Q15878 | 5/20 | 0.62 |
| ▸ | CACNA2D4 | Q7Z3S7 | 5/20 | 0.62 |
| ▸ | CACNA2D3 | Q8IZS8 | 5/20 | 0.62 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769719 | 0.90 | ALDH1A1 (0.65) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL7696757 | 0.84 | PLA2G2A (0.69) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769700 | 0.83 | LMNA (0.75) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL7698481 | 0.82 | LMNA (0.77) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769685 | 0.80 | ALDH1A1 (0.60) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769743 | 0.80 | LMNA (0.82) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL20769664 | 0.80 | LMNA (0.57) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769677 | 0.79 | LMNA (0.56) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL2008743 | 0.79 | PLA2G2A (0.70) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL18568331 | 0.78 | ICMT (0.60) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772592-B1 | 1H-INDOLE-1-FUNCTIONAL sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| EP-0772592-A4 | 1H-INDOLE-1-FUNCTIONAL sPLA 2? INHIBITORS | LILLY CO ELI (US) | 1998-07-08 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| US-5641800-A | ALLEVIATE EFFECT OF SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, AND RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0772592-A1 | 1H-INDOLE-1-FUNCTIONAL sPLA 2? INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003376-A1 | 1H-INDOLE-1-FUNCTIONAL sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |