SCHEMBL7054725

SCHEMBL7054725

CC1=Cc2c(-c3c[nH]c4ccccc34)cccc2C1[Si](C)(C)C1C(C)=Cc2c(-c3c[nH]c4ccccc34)cccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 2/20 0.38
MAPK1 P28482 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38
TUBB2A Q13885 1/20 0.38
TUBB8 Q3ZCM7 1/20 0.38
TUBA3E Q6PEY2 1/20 0.38
TUBA1A Q71U36 1/20 0.38
TUBA1C Q9BQE3 1/20 0.38
TUBB6 Q9BUF5 1/20 0.38
TUBB2B Q9BVA1 1/20 0.38
TUBB1 Q9H4B7 1/20 0.38
EDNRA P25101 1/20 0.38
MAPT P10636 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3149399 0.80 ENPP3 (0.38) MAPK1HSD17B10MAPTSMN1; SMN2ALDH1A1
SCHEMBL8574666 0.80 BCL2 (0.39) IMPDH2MAPK1HSD17B10TUBB4ATUBB
SCHEMBL5836701 0.78 RAB9A (0.37) MAPK1HSD17B10MAPTSMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL5167145 0.77 ENPP3 (0.36) MAPK1HSD17B10MAPTSMN1; SMN2ALDH1A1
SCHEMBL3144749 0.76 ALDH1A1 (0.37) MAPK1HSD17B10MAPTALDH1A1CYP1A2
SCHEMBL8573586 0.75 PTPRC (0.34) IMPDH2MAPK1HSD17B10TUBB4ATUBB
SCHEMBL29366427 0.75 PDCD1 (0.34) SMN1; SMN2ALDH1A1GPR55NPC1RAB9A
SCHEMBL26606290 0.75
SCHEMBL61908 0.75 PDCD1 (0.34) SMN1; SMN2ALDH1A1GPR55NPC1RAB9A
Hydrochloric Acid SCHEMBL5168428 0.74 ALDH1A1 (0.36) MAPK1HSD17B10ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed