Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790563 | 0.73 | TRPA1 (0.43) | SMN1; SMN2SLC6A4HTR2AKCNH2L3MBTL1 | |
| SCHEMBL24258323 | 0.70 | KMT2A (0.47) | SMN1; SMN2KCNH2NPSR1ALDH1A1 | |
| SCHEMBL7080588 | 0.70 | IDO1 (0.43) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 | |
| SCHEMBL91286 | 0.69 | POLB (0.40) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 | |
| SCHEMBL13179975 | 0.69 | L3MBTL1 (0.39) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 | |
| SCHEMBL5847393 | 0.69 | L3MBTL1 (0.39) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 | |
| SCHEMBL5847395 | 0.69 | CSNK2A1 (0.57) | L3MBTL1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL3759408 | 0.69 | L3MBTL1 (0.39) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 | |
| SCHEMBL281996 | 0.68 | MAPK1 (0.63) | TSHRSLC6A4HTR2AKCNH2L3MBTL1 | |
| SCHEMBL91283 | 0.67 | GPR84 (0.44) | TSHRSMN1; SMN2SLC6A4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236257-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade | PHARMACIA CORPORATION | 2003-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236257-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade | PLG, TFPI, PLAT | TSHR 2319/4885SMN1; SMN2 3924/4885SLC6A4 1336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.