Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27075764 | 0.90 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL709626 | 0.90 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL28765809 | 0.88 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL203423 | 0.87 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL203795 | 0.86 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL203516 | 0.86 | RAF1 (0.39) | SMN1; SMN2MEN1KMT2AHTTLMNA | |
| SCHEMBL4306278 | 0.85 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL8522022 | 0.84 | L3MBTL1 (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL248232 | 0.82 | MEN1 (0.36) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL205371 | 0.82 | PIN1 (0.41) | ALDH1A1SMN1; SMN2NPC1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060917-A1 | PROCESS FOR THE PREPARATION OF AZOXYSTROBIN | GSP CROP SCIENCE PVT. LTD, (IN) | 2017-04-13 | — | — | WO | disclosed |
| EP-2102174-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYNOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | ADAMA MAKHTESHIM LTD (IL) | 2017-03-08 | — | — | EP | disclosed |
| US-8552185-B2 | Preparation of azoxystrobin | SYNGENTA LIMITED (GB) | 2013-10-08 | — | — | US | disclosed |
| US-20130261303-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYANOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 2013-10-03 | — | — | US | disclosed |
| US-8471013-B2 | Process for the preparation of substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 2013-06-25 | — | — | US | disclosed |
| US-8124761-B2 | Coupling of methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate with 2-cyanophenyl in DMF with 2 mol % DABCO; significantly smaller amounts of this relatively expensive catalyst may be used without compromising the yield | SYNGENTA LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| EP-2308825-A1 | Process for the preparation of an intermediate for azoxystrobin | Syngenta Limited (GB) | 2011-04-13 | — | — | EP | disclosed |
| US-20100036124-A1 | PREPARATION OF AZOXYSTROBIN | SYNGENTA LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20090281316-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYANOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 2009-11-12 | — | — | US | disclosed |
| EP-2102174-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYNOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | MAKHTESHIM CHEMICAL WORKS LIMITED (IL) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008075341-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYNOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100036124-A1 | PREPARATION OF AZOXYSTROBIN | CYP51A1, CYP1B1, CYP2D6 | ALDH1A1 266/4885SMN1; SMN2 4281/4885MEN1 807/4885 |
| US-20090281316-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYANOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | TYR, PAH, ACR | ALDH1A1 962/4885SMN1; SMN2 4729/4885MEN1 4792/4885 |
| US-20130261303-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYANOPHENOXY-PYRIMIDINYLOXY-PHENYL ACRYLATE DERIVATIVES | TYR, PAH, ACR | ALDH1A1 963/4885SMN1; SMN2 4725/4885MEN1 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.