SCHEMBL7126782

SCHEMBL7126782

Oc1cccc(C(O)C(Cl)(Cl)Cl)c1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.44
HPGD P15428 3/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
ALDH1A1 P00352 2/20 0.44
ALOX15 P16050 2/20 0.44
HSD17B10 Q99714 2/20 0.44
ADAMTS4 O75173 1/20 0.44
EGFR P00533 1/20 0.44
FYN P06241 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP8 P22894 1/20 0.44
CA6 P23280 1/20 0.44
CDK2 P24941 1/20 0.44
MMP12 P39900 1/20 0.44
RECQL P46063 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ADAMTS5 Q9UNA0 1/20 0.44
TSHR P16473 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7131111 0.83 GABRA1 (0.48) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL7125981 0.81 ADRA2A (0.37) ADRB1ADRA2AADRB3ADRA2BADRA2C
SCHEMBL7118915 0.80 G6PD (0.37) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL7122079 0.80 MMP2 (0.37) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL7128980 0.80 ALDH1A1 (0.48) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL7118642 0.79 LMNA (0.44) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL7119116 0.76 ALDH1A1 (0.38) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL8582907 0.75 LMNA (0.55) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL5589720 0.73 ALDH1A1 (0.52) LMNAHPGDCA1CA2ALDH1A1
SCHEMBL10870391 0.72 CYP2D6 (0.35) ALDH1A1TSHRHIF1ACYP3A4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030144541-A1 Process for preparing alpha-halogenated retones RHODIA CHIMIE (FR) 2003-07-31 US disclosed
EP-1250303-A1 METHOD FOR PREPARING ALPHA-HALOGENATED KETONES RHODIA CHIMIE (FR) 2002-10-23 EP disclosed
WO-2001055067-A1 METHOD FOR PREPARING ALPHA-HALOGENATED KETONES RHODIA CHIMIE (FR) 2001-08-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030144541-A1 Process for preparing alpha-halogenated retones ADH1A, ADH1C, RER1 LMNA 2235/4885HPGD 2994/4885CA1 671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.