Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.53 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.49 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363053 | 0.88 | MAPT (0.46) | NPC1RAB9AHPGDLMNACYP3A4 | |
| SCHEMBL8427070 | 0.87 | NPC1 (0.63) | NPC1RAB9AHPGDLMNACYP3A4 | |
| SCHEMBL7129528 | 0.86 | NPC1 (0.61) | NPC1RAB9AHPGDLMNACYP3A4 | |
| SCHEMBL1274132 | 0.81 | NPC1 (0.61) | NPC1RAB9AHPGDLMNACYP3A4 | |
| Lithium Ion SCHEMBL10491553 | 0.79 | NPC1 (0.61) | NPC1RAB9AHPGDLMNACYP3A4 | |
| Potassium Ion SCHEMBL10491864 | 0.79 | NPC1 (0.61) | NPC1RAB9AHPGDLMNACYP3A4 | |
| SCHEMBL9762530 | 0.78 | NPC1 (0.65) | NPC1RAB9AHPGDLMNACYP3A4 | |
| SCHEMBL170073 | 0.78 | MAPT (0.65) | RAB9AHPGDLMNACYP3A4CYP2C19 | |
| SCHEMBL7332618 | 0.78 | RAB9A (0.80) | NPC1RAB9AHPGDLMNACYP3A4 | |
| Sulfuric Acid SCHEMBL9740504 | 0.78 | NPC1 (0.86) | NPC1RAB9AHPGDLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579826-B2 | Having a crosslinked polymer layer including an ultraviolet absorbing structure, e.g. containing a benzotriaxole moiety; protective coatings; durability; using a coloring reaction of an electron donating leuko dye with an electron acceptor | RICOH COMPANY LIMITED (JP) | 2003-06-17 | — | — | US | disclosed |
| US-6524377-B2 | Phenolic electron accepting color developer and electron donating coloring agent such as leuco dye; achieves color on heating; erasure on cooling; durability; reusable | RICOH COMPANY, LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| US-6503868-B2 | Phenolic electron accepting color developer and electron donating coloring agent; leuco dye; achieves color on heating; erasure on cooling; durability; reusable | RICOH COMPANY, LTD. (JP) | 2003-01-07 | — | — | US | disclosed |
| US-6410478-B1 | A LAYER COMPRISING COLORING AGENT(LEUCO DYE), COLOR DEVELOPERS AND DECOLORING PROMOTERS COATED ON A SUPPORT; IMAGE DISPLAYS AND AS A REWRITABLE PAPER | RICOH COMPANY, LTD. (JP) | 2002-06-25 | — | — | US | disclosed |
| US-20020072472-A1 | Reversible thermosensitive recording medium and image forming and erasing method using the recording medium | RICOH COMPANY LIMITED (JP) | 2002-06-13 | — | — | US | disclosed |
| US-20010039243-A1 | Reversible thermosensitive coloring composition and recording material using the composition and recording method using the recording material | TORII MASAFUMI (JP) | 2001-11-08 | — | — | US | disclosed |
| US-20010025587-A1 | Reversible thermosensitive coloring composition and recording material using the composition and recording method using the recording material | TORII MASAFUMI (JP) | 2001-10-04 | — | — | US | disclosed |
| US-6207613-B1 | ELECTRON ACCEPTING COLOR DEVELOPER INCLUDES A PHENOLIC COMPOUND | RICOH COMPANY, LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| US-5981429-A | AN ELECTRON-DONATING COLORING COMPOUND (COLORING AGENT) AND AN ELECTRON-ACCEPTING COMPOUND (DEVELOPER), CAPABLE OF INDUCING COLOR FORMATION BY REACTING BOTH COMPOUNDS, AND EARSING THE COLOR BY CONTROLLING HEAT ENERGY | RICOH COMPANY, LTD. (JP) | 1999-11-09 | — | — | US | disclosed |