Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956252 | 1.00 | TRPM8 (0.60) | TRPM8EPHX1TRPA1P2RX4ALDH1A1 | |
| SCHEMBL724576 | 1.00 | TRPM8 (0.60) | TRPM8EPHX1TRPA1P2RX4ALDH1A1 | |
| SCHEMBL720504 | 0.93 | TRPM8 (0.57) | TRPM8EPHX1TRPA1TRPV1 | |
| SCHEMBL720505 | 0.93 | TRPM8 (0.57) | TRPM8EPHX1TRPA1TRPV1 | |
| SCHEMBL18541154 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT | |
| SCHEMBL722923 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT | |
| SCHEMBL722922 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT | |
| SCHEMBL1115691 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT | |
| SCHEMBL358358 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT | |
| SCHEMBL31685892 | 0.91 | TRPM8 (0.71) | TRPM8EPHX1TRPA1TRPV1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250288583-A1 | Treatment of Mucus Hypersecretion | ALTA RESEARCH, LLC | 2025-09-18 | — | — | US | claimed |
| US-8853267-B2 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | AXALBION SA (CH) | 2014-10-07 | — | — | US | claimed |
| EP-2665492-A1 | (R)-1,2-PROPANEDIOL FOR USE AS A SOLVENT IN THERAPEUTIC COOLING AGENT COMPOSITIONS | Wei, Edward Tak (US) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098342-A1 | (R)-1,2-PROPANEDIOL FOR USE AS A SOLVENT IN THERAPEUTIC COOLING AGENT COMPOSITIONS | PAGET, HUGH, CHARLES, EDWARD (GB) | 2012-07-26 | — | — | WO | claimed |
| US-20120184614-A1 | N-alkylcarbonyl-amino acid ester compounds and their use for cough and pharyngitis | AXALBION SA (CH) | 2012-07-19 | — | — | US | claimed |
| US-20110152366-A1 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | AXALBION SA (CH) | 2011-06-23 | — | — | US | claimed |
| EP-1871738-B1 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | WEI EDWARD T (US) | 2009-07-15 | — | — | EP | claimed |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | WEI EDWARD TAK | 2008-09-18 | — | — | US | claimed |
| EP-1871738-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | Wei, Edward T. (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006103401-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | PAGET, HUGH, CHARLES, EDWARD (GB) | 2006-10-05 | — | — | WO | claimed |
| US-20250288583-A1 | Treatment of Mucus Hypersecretion | ALTA RESEARCH, LLC | 2025-09-18 | — | — | US | disclosed |
| US-20150105349-A1 | (R)-(-)-1,2-propanediol compositions and methods | ENERGY, UNITED STATES DEPARTMENT OF | 2015-04-16 | — | — | US | disclosed |
| US-8853267-B2 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | AXALBION SA (CH) | 2014-10-07 | — | — | US | disclosed |
| US-8853267-B2 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | AXALBION SA (CH) | 2014-10-07 | — | — | US | disclosed |
| US-8853267-B2 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | AXALBION SA (CH) | 2014-10-07 | — | — | US | disclosed |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | WEI EDWARD TAK | 2008-09-18 | — | — | US | disclosed |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | WEI EDWARD TAK | 2008-09-18 | — | — | US | disclosed |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | WEI EDWARD TAK | 2008-09-18 | — | — | US | disclosed |
| EP-1871738-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | Wei, Edward T. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006103401-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | PAGET, HUGH, CHARLES, EDWARD (GB) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105349-A1 | (R)-(-)-1,2-propanediol compositions and methods | ADH1C, ADH1A, CNR1 | TRPM8 166/4885EPHX1 2408/4885TRPA1 82/4885 |
| US-20120184614-A1 | N-alkylcarbonyl-amino acid ester compounds and their use for cough and pharyngitis | TRPA1, FAAH, TRPV1 | TRPM8 49/4885EPHX1 837/4885TRPA1 1/4885 |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | TRPA1, TRPV1, CYSLTR1 | TRPM8 22/4885EPHX1 1517/4885TRPA1 1/4885 |
| US-20250288583-A1 | Treatment of Mucus Hypersecretion | TRPM8, GPR18, OPRL1 | TRPM8 1/4885EPHX1 771/4885TRPA1 10/4885 |
| US-20110152366-A1 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain | TRPA1, TRPV1, CUTA | TRPM8 41/4885EPHX1 1021/4885TRPA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.