Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYB5R3 | P00387 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753726 | 0.89 | LMNA (0.45) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL5576227 | 0.77 | CYP1A2 (0.50) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL10144132 | 0.77 | PTGS2 (0.47) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL2655184 | 0.75 | DHFR (0.41) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL10986918 | 0.75 | LMNA (0.45) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL8552122 | 0.75 | SOD1 (0.37) | SOD1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL8748369 | 0.75 | RAB9A (0.40) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL3979841 | 0.74 | CYP1A2 (0.47) | SOD1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7093315 | 0.73 | PTGS2 (0.43) | RAB9ASMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL19002781 | 0.73 | PTGS2 (0.51) | RAB9ASMN1; SMN2LMNAGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030036557-A1 | Heterocyclo-substituted imidazoles for the treatment of inflammation | G.D. SEARLE & CO. | 2003-02-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036557-A1 | Heterocyclo-substituted imidazoles for the treatment of inflammation | HCK, IL4I1, AHR | SOD1 1693/4885RAB9A 2982/4885SMN1; SMN2 4695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.