Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6244930 | 0.79 | GPR55 (0.47) | MAOBSMN1; SMN2KDM4EHSD17B10MEN1 | |
| SCHEMBL8630704 | 0.76 | NPC1 (0.48) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL9347721 | 0.74 | NPC1 (0.42) | SMN1; SMN2HPGDKDM4EMEN1TP53 | |
| SCHEMBL9347252 | 0.74 | PTGS2 (0.41) | CASP3SENP8SENP7SENP6MAOB | |
| SCHEMBL9616811 | 0.71 | ENPP3 (0.58) | CASP3SENP7MAOBSMN1; SMN2HPGD | |
| SCHEMBL986607 | 0.68 | ALDH1A1 (0.63) | CASP3SENP8SENP7SENP6MAOA | |
| Bicarbonate SCHEMBL6431103 | 0.66 | ALDH1A1 (0.62) | MAOASMN1; SMN2HPGDKDM4EHSD17B10 | |
| SCHEMBL29623192 | 0.66 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6MAOA | |
| SCHEMBL30442890 | 0.66 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6MAOA | |
| SCHEMBL28574 | 0.66 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140039199-A1 | PROCESS FOR THE PREPARATION OF DEFERASIROX | ALEMBIC PHARMACEUTICALS, LTD. (IN) | 2014-02-06 | — | — | US | claimed |
| EP-2632907-B1 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | DAVULURI RAMAMOHAN RAO (IN) | 2015-10-14 | — | — | EP | disclosed |
| EP-2632907-B1 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | DAVULURI RAMAMOHAN RAO (IN) | 2015-10-14 | — | — | EP | disclosed |
| US-8907083-B2 | Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-IH-I, 2, 4-triazolTI-yl] benzoic acid | RAMAMOHAN RAO DAVULURI (IN) | 2014-12-09 | — | — | US | disclosed |
| US-8907083-B2 | Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-IH-I, 2, 4-triazolTI-yl] benzoic acid | RAMAMOHAN RAO DAVULURI (IN) | 2014-12-09 | — | — | US | disclosed |
| EP-2632907-A4 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | DAVULURI RAMAMOHAN RAO (IN) | 2014-07-09 | — | — | EP | disclosed |
| US-20130338356-A1 | Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-lH-l , 2, 4-triazolTl-yl] benzoic acid | DAVULURI, RAMAMOHAN RAO (IN) | 2013-12-19 | — | — | US | disclosed |
| US-20130338356-A1 | Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-lH-l , 2, 4-triazolTl-yl] benzoic acid | DAVULURI, RAMAMOHAN RAO (IN) | 2013-12-19 | — | — | US | disclosed |
| EP-2632907-A2 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | Davuluri, Ramamohan Rao (IN) | 2013-09-04 | — | — | EP | disclosed |
| EP-2632907-A2 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | Davuluri, Ramamohan Rao (IN) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012025935-A3 | PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX | DAVULURI RAMAMOHAN RAO (IN) | 2012-04-19 | — | — | WO | disclosed |
| WO-2012025935-A2 | A PROCESS FOR THE PREPARATION OF 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARATION OF 4-[3, 5-BIS (2-HYDROXYPHENYL)-1H-1, 2, 4-TRIAZOL-1-YL] BENZOIC ACID | DAVULURI RAMAMOHAN RAO (IN) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025935-A2 | A PROCESS FOR THE PREPARATION OF 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARATION OF 4-[3, 5-BIS (2-HYDROXYPHENYL)-1H-1, 2, 4-TRIAZOL-1-YL] BENZOIC ACID | DAVULURI RAMAMOHAN RAO (IN) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025935-A2 | A PROCESS FOR THE PREPARATION OF 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARATION OF 4-[3, 5-BIS (2-HYDROXYPHENYL)-1H-1, 2, 4-TRIAZOL-1-YL] BENZOIC ACID | DAVULURI RAMAMOHAN RAO (IN) | 2012-03-01 | — | — | WO | disclosed |
| EP-2108013-A2 | CRYSTALLINE FORMS OF DEFERASIROX | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság (HU) | 2009-10-14 | — | — | EP | disclosed |
| US-20080262060-A1 | Crystalline forms of Deferasirox | TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG (HU) | 2008-10-23 | — | — | US | disclosed |
| WO-2008094617-A2 | CRYSTALLINE FORMS OF DEFERASIROX | TEVA GYÓGYSZERGYÁR ZÁRTKÖRÜEN MÜKÖDÖ RÉSZVÉNYTÁRSASÁG (HU) | 2008-08-07 | — | — | WO | disclosed |
| US-20050235428-A1 | Use of metal complex compounds as oxidation catalysts | CIBA SPECIALTY CHEMICALS CORP. | 2005-10-27 | — | — | US | disclosed |
| EP-1456216-A1 | USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS | Ciba SC Holding AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053986-A1 | USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039199-A1 | PROCESS FOR THE PREPARATION OF DEFERASIROX | HAMP, FECH, SLC40A1 | CASP3 3786/4885SENP8 2392/4885SENP7 1206/4885 |
| US-20080262060-A1 | Crystalline forms of Deferasirox | SLC40A1, FECH, SFXN3 | CASP3 2682/4885SENP8 2025/4885SENP7 1609/4885 |
| US-20130338356-A1 | Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-lH-l , 2, 4-triazolTl-yl] benzoic acid | HPD, HACL2, TST | CASP3 4142/4885SENP8 3040/4885SENP7 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.