SCHEMBL725997

SCHEMBL725997

Cc1ccc(N)nc1-c1cccc(C(=O)OC(C)(C)C)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.43
ABCG2 Q9UNQ0 2/20 0.41
ABCB1 P08183 1/20 0.41
LHCGR P22888 1/20 0.39
GRM6 O15303 1/20 0.38
MAP2K4 P45985 1/20 0.38
STAT3 P40763 1/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
SDHB P21912 1/20 0.36
GPR119 Q8TDV5 1/20 0.35
DHFR P00374 1/20 0.35
LIPC P11150 1/20 0.35
LIPG Q9Y5X9 1/20 0.35
HPGDS O60760 1/20 0.35
LDHA P00338 1/20 0.35
ADK P55263 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31049680 1.00 SLC7A5 (0.43) SLC7A5ABCG2ABCB1LHCGRGRM6
SCHEMBL27826923 0.89 ALDH1A1 (0.48) MAP2K4CA12CA1CA2CA9
SCHEMBL18425126 0.88 ABCG2 (0.41) SLC7A5ABCG2ABCB1MAP2K4SDHB
SCHEMBL28669756 0.86 SLC7A5 (0.42) SLC7A5ABCG2ABCB1LHCGRMAP2K4
SCHEMBL15316160 0.86 CA12 (0.48) CA12CA1CA2CA9SDHB
SCHEMBL19439096 0.85 ABCG2 (0.41) SLC7A5ABCG2ABCB1LHCGRMAP2K4
SCHEMBL2031607 0.84 ALDH1A1 (0.41) SLC7A5ABCG2ABCB1LHCGRSTAT3
SCHEMBL28663539 0.84 CA12 (0.49) ABCG2GRM6STAT3CA12CA1
SCHEMBL16237574 0.84 TP53 (0.47)
SCHEMBL1014741 0.83 SLC7A5 (0.41) SLC7A5ABCG2ABCB1LHCGRGRM6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108506-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED 2026-04-23 US disclosed
US-20260092047-A1 MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR VERTEX PHARMA (US) 2026-04-02 US disclosed
EP-4218754-B1 VANZACAFTOR FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS VERTEX PHARMA (US) 2026-03-25 EP disclosed
US-12508231-B2 Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-12-30 US disclosed
US-12384762-B2 Modulator of the Cystic Fibrosis Transmembrane Conductance Regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-08-12 US disclosed
US-12350262-B2 Methods of treatment for cystic fibrosis VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-07-08 US disclosed
EP-3880197-B9 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMA (US) 2025-07-02 EP disclosed
EP-4556008-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES Vertex Pharmaceuticals Incorporated (US) 2025-05-21 EP disclosed
EP-3470063-B1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES VERTEX PHARMA (US) 2025-01-01 EP disclosed
US-20240368189-A1 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulators VERTEX PHARMA (US) 2024-11-07 US disclosed
US-20090176989-A1 PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS VERTEX PHARMACEUTICALS INCORPORATED 2009-07-09 US disclosed
US-20090176989-A1 PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS VERTEX PHARMACEUTICALS INCORPORATED 2009-07-09 US disclosed
US-20090170905-A1 SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID VERTEX PHARMACEUTICALS INCORPORATED 2009-07-02 US disclosed
WO-2009076142-A2 PROCESSES FOR PRODUCING CYCLOALKYLCARBOXIAMIDO-PYRIDINE BENZOIC ACIDS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-06-18 WO disclosed
WO-2009076142-A2 PROCESSES FOR PRODUCING CYCLOALKYLCARBOXIAMIDO-PYRIDINE BENZOIC ACIDS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-06-18 WO disclosed
WO-2009076141-A2 FORMULATIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCKLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-06-18 WO disclosed
WO-2009073757-A1 SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3] DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL) BENZOIC ACID VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-06-11 WO disclosed
US-20080286204-A1 MODULATORS OF CFTR VERTEX PHARMACEUTICALS INCORPORATED 2008-11-20 US disclosed
US-20080286204-A1 MODULATORS OF CFTR VERTEX PHARMACEUTICALS INCORPORATED 2008-11-20 US disclosed
US-20080286204-A1 MODULATORS OF CFTR VERTEX PHARMACEUTICALS INCORPORATED 2008-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12350262-B2 Methods of treatment for cystic fibrosis CFTR, SLC26A4, SCNN1B SLC7A5 605/4885ABCG2 566/4885ABCB1 122/4885
US-20090176989-A1 PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS DDC, PCCA, KMO SLC7A5 3606/4885ABCG2 3036/4885ABCB1 3051/4885
US-20260108506-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS CFTR, CLCN2, SCNN1B SLC7A5 554/4885ABCG2 244/4885ABCB1 135/4885
US-12384762-B2 Modulator of the Cystic Fibrosis Transmembrane Conductance Regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator CFTR, SLC26A4, TMEM109 SLC7A5 1051/4885ABCG2 68/4885ABCB1 36/4885
US-20080286204-A1 MODULATORS OF CFTR CFTR, ABCB1, ABCC4 SLC7A5 350/4885ABCG2 19/4885ABCB1 2/4885
US-20240368189-A1 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulators CFTR, SLC26A4, ABCB11 SLC7A5 893/4885ABCG2 104/4885ABCB1 11/4885
US-20260092047-A1 MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR CFTR, SLC26A3, SLC26A4 SLC7A5 777/4885ABCG2 178/4885ABCB1 78/4885
US-20090170905-A1 SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CALU, CA5B SLC7A5 2350/4885ABCG2 50/4885ABCB1 409/4885
US-12508231-B2 Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid CFTR, MFAP1, CMA1 SLC7A5 3202/4885ABCG2 398/4885ABCB1 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.