Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260676 | 0.85 | L3MBTL1 (0.41) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL8539617 | 0.79 | KCNN4 (0.44) | ALDH1A1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12748014 | 0.78 | AGTR1 (0.46) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL7078741 | 0.76 | PTGS2 (0.31) | PTGS2 | |
| SCHEMBL13232452 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL9571283 | 0.75 | MAOB (0.52) | — | |
| SCHEMBL7647188 | 0.74 | POLB (0.41) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL8036362 | 0.72 | LMNA (0.50) | ALDH1A1TSHRMEN1KMT2APTGS2 | |
| SCHEMBL635 | 0.71 | AGTR1 (0.51) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL6360839 | 0.71 | P2RX7 (0.62) | ALDH1A1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003066627-A1 | DEUTERATED SPIROCYCLOPENTANIMIDAZOLINONES AND THE USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISEASES | TURICUM DRUG DEVELOPMENT AG (CH) | 2003-08-14 | — | — | WO | disclosed |
| EP-0643709-A1 | 4-(1-$i(H)-PYRROL-1-YL)IMIDAZOLES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1995-03-22 | — | — | EP | disclosed |
| EP-0291969-B1 | Tetrazole intermediates to antihypertensive compounds | DU PONT (US) | 1994-02-16 | — | — | EP | disclosed |
| US-5276048-A | 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity | WARNER-LAMBERT COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| US-5210211-A | 4-(1H-PYRROL-1-YL) IMIDAZOLES WITH ANGIOTENSION II ANTAGONIST ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1993-05-11 | — | — | US | disclosed |
| WO-1993000341-A1 | 4-(1-H-PYRROL-1-YL)IMIDAZOLES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1993-01-07 | — | — | WO | disclosed |
| US-4874867-A | Tetrazole intermediates to antihypertensive compounds | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| US-4870186-A | Tetrazole intermediates to antihypertensive compounds | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-09-26 | — | — | US | disclosed |
| US-4820843-A | Tetrazole intermediates to antihypertensive compounds | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0291969-A2 | Tetrazole intermediates to antihypertensive compounds | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |