Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9403502 | 0.95 | ALDH1A1 (0.38) | ALDH1A1TP53CYP3A4MAPK1CYP2C19 | |
| SCHEMBL9610 | 0.82 | ATM (0.33) | ALDH1A1CYP3A4MAPK1CYP2C19SMN1; SMN2 | |
| SCHEMBL1564313 | 0.78 | ALDH1A1 (0.35) | ALDH1A1TP53CYP3A4MAPK1CYP2C19 | |
| SCHEMBL11811453 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPK1CYP2C19SMN1; SMN2 | |
| SCHEMBL1616226 | 0.77 | GLI1 (0.33) | — | |
| SCHEMBL711832 | 0.77 | ATM (0.34) | CYP2C19SMN1; SMN2PPM1BPTPN1PPP1CC | |
| SCHEMBL1230557 | 0.77 | ALDH1A1 (0.41) | ALDH1A1PPM1BPTPN1PPP1CCPOLB | |
| SCHEMBL14248496 | 0.77 | ALDH1A1 (0.41) | ALDH1A1PPM1BPTPN1PPP1CCPOLB | |
| SCHEMBL3388688 | 0.76 | KMT2A (0.35) | ALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL21404205 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TP53CYP3A4MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
| EP-1914232-B1 | N-DIHYDROXYALKYL-SUBSTITUTED 2-OXOIMIDAZOLE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2010-12-15 | — | — | EP | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20080103178-A1 | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives | MSD K.K. (JP) | 2008-05-01 | — | — | US | disclosed |
| US-7300947-B2 | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-11-27 | — | — | US | disclosed |
| US-20070015792-A1 | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives | MSD K.K. (JP) | 2007-01-18 | — | — | US | disclosed |
| US-6977262-B2 | Dihydropyrazolopyridine compounds and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2005-12-20 | — | — | US | disclosed |
| US-20040052822-A1 | Dihydropyrazolopyridine compounds and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2004-03-18 | — | — | US | disclosed |
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002028183-A1 | FUNGICIDES | SYNGENTA LIMITED (GB) | 2002-04-11 | — | — | WO | disclosed |
| US-6043261-A | TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA, CEREBRAL ISCHEMIA, THROMBOTIC STROKE, GLOBAL ISCHEMIA, NERVOUS SYSTEM DISORDERS | G. D. SEARLE & CO. (US) | 2000-03-28 | — | — | US | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015792-A1 | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives | OPRL1, OPRK1, GPR119 | ALDH1A1 1536/4885TP53 2835/4885CYP3A4 4339/4885 |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | ADRM1, PNMT, ACMSD | ALDH1A1 1163/4885TP53 1856/4885CYP3A4 20/4885 |
| US-20040052822-A1 | Dihydropyrazolopyridine compounds and pharmaceutical use thereof | GSK3B, GSK3A, PYGB | ALDH1A1 944/4885TP53 736/4885CYP3A4 1271/4885 |
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | ALDH1A1 4674/4885TP53 3696/4885CYP3A4 2257/4885 |
| US-20080103178-A1 | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives | OPRL1, OPRK1, GPR119 | ALDH1A1 1536/4885TP53 2835/4885CYP3A4 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.