SCHEMBL728128

SCHEMBL728128

O=S(=O)(COc1ccccc1)Nc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 3/20 0.56
AR P10275 6/20 0.54
HPGD P15428 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
KMT2A Q03164 2/20 0.46
KEAP1 Q14145 2/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
MAPT P10636 2/20 0.45
MEN1 O00255 1/20 0.45
HTT P42858 1/20 0.45
IL1RN P18510 1/20 0.44
ERAP1 Q9NZ08 1/20 0.44
PKM P14618 1/20 0.43
RECQL P46063 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27767404 0.78 MAOA (0.43) PGRARSMN1; SMN2KMT2ACA1
SCHEMBL5346498 0.78 CA1 (0.52) PGRARHPGDKMT2AKEAP1
SCHEMBL14123868 0.78 RAB9A (0.48) PGRARHPGDNPC1RAB9A
SCHEMBL4905930 0.76 AR (0.44) PGRARHPGDKMT2AMAPT
SCHEMBL6007495 0.76 CA1 (0.48) PGRARHPGDKMT2AKEAP1
SCHEMBL6007503 0.76 KEAP1 (0.44) PGRARHPGDKMT2AKEAP1
SCHEMBL15672897 0.74 CA2 (0.56) PGRARHPGDSMN1; SMN2KMT2A
SCHEMBL1674268 0.74 KCNA3 (0.50) KMT2ACA1CA2PKMRECQL
SCHEMBL6533144 0.74 CA1 (0.56) PGRARHPGDKMT2AKEAP1
SCHEMBL633995 0.74 KMT2A (0.76) PGRARHPGDKMT2ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2011524358-A 2011-09-01 JP claimed
EP-2320893-A1 COMBINATION OF A TRIPTAN AND AN NSAID Elan Pharma International Limited (IE) 2011-05-18 EP claimed
US-20090311335-A1 COMBINATION OF A TRIPTAN AND AN NSAID ALKERMES, INC. 2009-12-17 US claimed
WO-2009152192-A1 COMBINATION OF A TRIPTAN AND AN NSAID ELAN PHARMA INTERNATIONAL LIMITED (IE) 2009-12-17 WO claimed
EP-1617816-B1 NANOPARTICULATE MELOXICAN FORMULATIONS ELAN PHARMA INT LTD (IE) 2009-05-13 EP claimed
EP-1938803-A2 Formulations comprising nanoparticulate meloxican Elan Pharma International Limited (IE) 2008-07-02 EP claimed
EP-1617816-A2 NANOPARTICULATE MELOXICAN FORMULATIONS Elan Pharma International Limited (IE) 2006-01-25 EP claimed
WO-2005002542-A2 NANOPARTICULATE MELOXICAN FORMULATIONS ELAN PHARMA INTERNATIONAL LTD. (IE) 2005-01-13 WO claimed
US-20040229038-A1 Nanoparticulate meloxicam formulations ELAN PHARMA INTERNATIONAL LTD. 2004-11-18 US claimed
US-20210113580-A1 NANOPARTICULATE MELOXICAM FORMULATIONS BAUDAX BIO, INC. 2021-04-22 US disclosed
EP-3434261-B1 FORMULATIONS COMPRISING NANOPARTICULATE MELOXICAM BAUDAX BIO INC (US) 2020-10-28 EP disclosed
US-10709713-B2 Nanoparticulate meloxicam formulations BAUDAX BIO, INC. (US) 2020-07-14 US disclosed
US-20200155564-A1 Nanoparticulate Meloxicam Formulations RECRO TECHNOLOGY LLC 2020-05-21 US disclosed
US-10471067-B2 Nanoparticulate meloxicam formulations RECRO PHARMA, INC. (US) 2019-11-12 US disclosed
EP-1651189-A1 NOVEL METAXALONE COMPOSITIONS Elan Pharma International Limited (IE) 2006-05-03 EP disclosed
EP-1617816-A2 NANOPARTICULATE MELOXICAN FORMULATIONS Elan Pharma International Limited (IE) 2006-01-25 EP disclosed
US-20050063913-A1 Novel metaxalone compositions ELAN PHARMA INTERNATIONAL, LTD. 2005-03-24 US disclosed
WO-2005016310-A1 NOVEL METAXALONE COMPOSITIONS ELAN PHARMA INTERNATIONAL LTD. (IE) 2005-02-24 WO disclosed
WO-2005002542-A2 NANOPARTICULATE MELOXICAN FORMULATIONS ELAN PHARMA INTERNATIONAL LTD. (IE) 2005-01-13 WO disclosed
US-20040229038-A1 Nanoparticulate meloxicam formulations ELAN PHARMA INTERNATIONAL LTD. 2004-11-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050063913-A1 Novel metaxalone compositions MTX1, MTX2, TBXA2R PGR 1583/4885AR 1575/4885HPGD 358/4885
US-20200155564-A1 Nanoparticulate Meloxicam Formulations MTNR1A, MB, MTDH PGR 2695/4885AR 3770/4885HPGD 347/4885
US-10709713-B2 Nanoparticulate meloxicam formulations MTNR1A, MB, MTDH PGR 2695/4885AR 3770/4885HPGD 347/4885
US-10471067-B2 Nanoparticulate meloxicam formulations MTNR1A, MB, MTDH PGR 2695/4885AR 3770/4885HPGD 347/4885
US-20210113580-A1 NANOPARTICULATE MELOXICAM FORMULATIONS MTNR1A, MB, MTDH PGR 2695/4885AR 3770/4885HPGD 347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.