Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 3/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303150 | 0.92 | ALDH1A1 (0.38) | ALDH1A1GRM4POLBSMN1; SMN2KDM4E | |
| SCHEMBL7302866 | 0.83 | ALDH1A1 (0.36) | ALDH1A1POLBL3MBTL1SCD | |
| SCHEMBL3565608 | 0.82 | LMNA (0.32) | — | |
| SCHEMBL7296204 | 0.82 | HSD11B1 (0.43) | ALDH1A1POLBL3MBTL1 | |
| SCHEMBL7298731 | 0.82 | HSD11B1 (0.43) | ALDH1A1POLBL3MBTL1 | |
| SCHEMBL563868 | 0.79 | LMNA (0.46) | ALDH1A1POLBL3MBTL1SMN1; SMN2USP19 | |
| SCHEMBL9835659 | 0.77 | BACE1 (0.37) | ALDH1A1POLBL3MBTL1 | |
| SCHEMBL7291911 | 0.74 | ALOX15 (0.37) | ALDH1A1SMN1; SMN2SCD5SCDGAA | |
| SCHEMBL7302874 | 0.73 | ROCK2 (0.41) | ALDH1A1POLBSMN1; SMN2KDM4E | |
| SCHEMBL7295669 | 0.73 | ROCK2 (0.41) | ALDH1A1POLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |