Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302874 | 1.00 | ROCK2 (0.41) | ROCK2HSD11B1ITGA4SMN1; SMN2ALOX15 | |
| SCHEMBL7296204 | 0.92 | HSD11B1 (0.43) | ROCK2HSD11B1RENALDH1A1NPC1 | |
| SCHEMBL7298731 | 0.92 | HSD11B1 (0.43) | ROCK2HSD11B1RENALDH1A1NPC1 | |
| SCHEMBL7291911 | 0.82 | ALOX15 (0.37) | ROCK2ITGA4SMN1; SMN2ALOX15MAPT | |
| SCHEMBL9835659 | 0.82 | BACE1 (0.37) | ROCK2HSD11B1ALDH1A1PKMPOLB | |
| SCHEMBL7303150 | 0.81 | ALDH1A1 (0.38) | SMN1; SMN2ALOX15MAPTALDH1A1PKM | |
| SCHEMBL9615855 | 0.77 | BCL2 (0.46) | ALOX15ALDH1A1PKMPOLB | |
| SCHEMBL7302866 | 0.74 | ALDH1A1 (0.36) | ROCK2ALDH1A1POLB | |
| SCHEMBL7294550 | 0.73 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1POLBKDM4E | |
| SCHEMBL7300912 | 0.73 | SLC5A1 (0.31) | SMN1; SMN2ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |