SCHEMBL7300020

SCHEMBL7300020

[O-][n+]1cc(Nc2ccon2)cc2c1CCOC2

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 2/20 0.34
BACE2 Q9Y5Z0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7304944 0.67 ANO1 (0.38)
SCHEMBL5765529 0.59 KMT2A (0.50) BACE1
SCHEMBL7304154 0.57 BACE1 (0.35) BACE1BACE2
SCHEMBL5788078 0.56 RAB9A (0.43) BACE1BACE2
SCHEMBL23794891 0.56 MAPK10 (0.50) BACE1BACE2
SCHEMBL23794887 0.56 RAB9A (0.60) BACE1BACE2
SCHEMBL23794893 0.56 MAPT (0.48)
SCHEMBL23794894 0.56 AURKA (0.49) BACE1BACE2
SCHEMBL73115 0.55 BACE1 (0.45) BACE1
SCHEMBL23794896 0.53 RAB9A (0.59)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0556008-B1 Condensed imidazopyridine derivatives with psychotropic activity SHIONOGI & CO (JP) 1997-05-14 EP disclosed
US-5461062-A Psychotropic agent as antianxiety agent, anesthesia antagonistic agent SHIONOGI & CO., LTD. (JP) 1995-10-24 US disclosed
US-5378848-A Benzodiazepine agonist, psychotropic, antianxiety, cerebral function activator, anesthesia atagonist SHIONOGI & CO., LTD. (JP) 1995-01-03 US disclosed
EP-0556008-A1 Condensed imidazopyridine derivatives with psychotropic activity SHIONOGI & CO., LTD. (JP) 1993-08-18 EP disclosed