Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | LIPE | Q05469 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 9/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301657 | 0.85 | RXRB (0.39) | RXRBLIPEGRIN2BP2RX3SCN9A | |
| SCHEMBL7303122 | 0.83 | ALDH1A1 (0.34) | — | |
| SCHEMBL7310773 | 0.67 | MMP1 (0.41) | — | |
| SCHEMBL7303105 | 0.65 | LIPE (0.45) | LIPEP2RX3SCN9AFPR2 | |
| SCHEMBL7307841 | 0.63 | MMP2 (0.43) | LIPEP2RX3SCN9AFPR2 | |
| SCHEMBL6932786 | 0.62 | CTSL (0.39) | — | |
| SCHEMBL8424066 | 0.62 | HPGD (0.43) | — | |
| SCHEMBL8626757 | 0.61 | OPRM1 (0.48) | LIPEGRIN2BP2RX3SCN9AEGLN1 | |
| SCHEMBL5689691 | 0.60 | LIPE (0.51) | LIPEFAAH | |
| SCHEMBL8425464 | 0.60 | S1PR5 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |