Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653099 | 0.89 | HDAC1 (0.43) | HDAC1HDAC8HDAC6TYMP | |
| SCHEMBL7302539 | 0.88 | MAT2A (0.44) | MAT2ATYMPHTR7 | |
| SCHEMBL7309368 | 0.86 | MAT2A (0.44) | MAT2AHDAC1HDAC8HDAC6TYMP | |
| SCHEMBL7301671 | 0.82 | MAT2A (0.48) | MAT2AHDAC6TYMP | |
| SCHEMBL7650175 | 0.80 | PARP1 (0.50) | TYMPHTR7 | |
| SCHEMBL7650556 | 0.80 | PARP1 (0.43) | TYMPMEN1KMT2A | |
| SCHEMBL7309296 | 0.78 | TDP1 (0.47) | MAT2A | |
| SCHEMBL7651942 | 0.78 | ALDH1A1 (0.53) | MAT2AMEN1KMT2A | |
| SCHEMBL9721440 | 0.76 | LMNA (0.53) | HTR7MEN1KMT2A | |
| SCHEMBL7312723 | 0.76 | HTR1A (0.57) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |