Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 6/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.33 |
| ▸ | ITGAL | P20701 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300912 | 0.93 | SLC5A1 (0.31) | — | |
| SCHEMBL7302866 | 0.88 | ALDH1A1 (0.36) | ITGB2ICAM1ITGAL | |
| SCHEMBL7291911 | 0.82 | ALOX15 (0.37) | — | |
| SCHEMBL7298731 | 0.72 | HSD11B1 (0.43) | ITGB2ICAM1ITGAL | |
| SCHEMBL7294550 | 0.72 | ALDH1A1 (0.35) | — | |
| SCHEMBL7296204 | 0.72 | HSD11B1 (0.43) | ITGB2ICAM1ITGAL | |
| SCHEMBL9835659 | 0.69 | BACE1 (0.37) | ITGB2ICAM1ITGAL | |
| SCHEMBL3565608 | 0.66 | LMNA (0.32) | — | |
| SCHEMBL7302874 | 0.66 | ROCK2 (0.41) | — | |
| SCHEMBL7295669 | 0.66 | ROCK2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |