Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | DHPS | P49366 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748457 | 0.78 | DHPS (0.50) | KMT2AMEN1HPGDDHPSNFE2L2 | |
| SCHEMBL2062610 | 0.76 | PIN1 (0.47) | HTR1ASLC6A2SLC6A4SLC6A3HPGD | |
| SCHEMBL7303200 | 0.75 | NPBWR1 (0.48) | KMT2AMEN1DHPSLRRK2NFE2L2 | |
| SCHEMBL7298131 | 0.75 | TRPA1 (0.45) | KMT2AMEN1HPGDDHPSLRRK2 | |
| SCHEMBL1627720 | 0.73 | NFE2L2 (0.50) | KMT2AHPGDARSMN1; SMN2NFE2L2 | |
| SCHEMBL29669870 | 0.73 | NFE2L2 (0.50) | KMT2AHPGDARSMN1; SMN2NFE2L2 | |
| Pyrimidine SCHEMBL628523 | 0.72 | DHPS (0.45) | KMT2AMEN1HPGDDHPSNFE2L2 | |
| SCHEMBL3993731 | 0.71 | AR (0.55) | HTR1ASLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL305881 | 0.71 | HTR1A (0.43) | HTR1ASLC6A2SLC6A4SLC6A3DHPS | |
| SCHEMBL1619631 | 0.69 | SMN1; SMN2 (0.52) | HTR1ASLC6A2SLC6A4SLC6A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |