Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 8/20 | 0.39 |
| ▸ | MMP9 | P14780 | 8/20 | 0.39 |
| ▸ | MMP2 | P08253 | 7/20 | 0.39 |
| ▸ | MMP8 | P22894 | 6/20 | 0.39 |
| ▸ | MMP12 | P39900 | 6/20 | 0.39 |
| ▸ | MMP14 | P50281 | 6/20 | 0.39 |
| ▸ | MMP16 | P51512 | 6/20 | 0.39 |
| ▸ | MMP3 | P08254 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319926 | 0.88 | MMP2 (0.43) | MAPTKMT2AMMP13MMP9MMP2 | |
| SCHEMBL7317370 | 0.84 | MMP9 (0.44) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7322262 | 0.79 | LMNA (0.43) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7311156 | 0.79 | KDM4E (0.44) | MAPTKMT2AMMP13MMP9MMP2 | |
| SCHEMBL27530282 | 0.79 | KEAP1 (0.41) | TDP1KMT2AAURKACASP3SENP8 | |
| SCHEMBL7311850 | 0.78 | KDM4E (0.42) | MAPTTDP1KMT2AMMP13MMP9 | |
| SCHEMBL7325399 | 0.78 | FFAR4 (0.54) | MAPTKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL7319136 | 0.77 | SMN1; SMN2 (0.40) | MAPTTDP1KMT2AMMP13MMP9 | |
| SCHEMBL7318787 | 0.76 | MMP13 (0.48) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7324047 | 0.76 | GABRG2 (0.42) | KMT2AMMP13MMP9MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |