Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.44 |
| ▸ | CA1 known ✓ | P00915 | 5/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.41 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL2502617 | 0.84 | CA7 (0.39) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL9550780 | 0.84 | CA12 (0.39) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL2497018 | 0.84 | CA12 (0.39) | CA7CA9CA12CA14CA1 | |
| Cyclopentanamine SCHEMBL11415557 | 0.83 | CA12 (0.37) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL29018094 | 0.83 | CA12 (0.40) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL10786807 | 0.82 | ALDH1A1 (0.38) | CA7CA9CA12CA14CA1 | |
| Cyclohexane SCHEMBL29085789 | 0.80 | CA1 (0.42) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL27711124 | 0.79 | CA1 (0.42) | CA7CA9CA12CA14CA1 | |
| Cyclohexylamine SCHEMBL7357483 | 0.79 | CA1 (0.42) | CA7CA9CA12CA14CA1 | |
| Cyclopentanamine SCHEMBL17102897 | 0.79 | CA12 (0.34) | CA7CA9CA12CA14CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101257886-A | Agent for simultaneous lightening and coloring of keratin fibres containing a sulfamate bleach booster | PROCTER & GAMBLE (US) | 2008-09-03 | — | — | CN | disclosed |
| US-5955576-A | PEPTIDE ALDEHYDE ANALOGS THAT INHIBIT THROMBIN OR FACTOR XA; FOR PREVENTION OR TREATMENT OF ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0684830-B1 | INHIBITORS OF THROMBOSIS | CORVAS INT INC (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0664786-B1 | ARGININE KETO-AMIDE ENZYME INHIBITORS | CORVAS INT INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5886146-A | N-ACYLATED OR SULFONATED TRIPEPTIDES FROM PROLINE, ARGININE AND AMINO ACID WITH CARBOXY OR TETRAZOLE GROUP | CORVAS INTERNATIONAL, INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5869454-A | ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5597804-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0684830-A4 | INHIBITORS OF THROMBOSIS. | CORVAS INT INC (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0684830-A1 | INHIBITORS OF THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994017817-A1 | INHIBITORS OF THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1994-08-18 | — | — | WO | disclosed |