Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401588 | 0.81 | NAALAD2 (0.42) | CYP1A2CYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7366777 | 0.80 | HSD11B1 (0.42) | CYP1A2ALDH1A1 | |
| SCHEMBL7364668 | 0.80 | ANPEP (0.37) | CYP1A2CYP2C9CYP2C19ALDH1A1KDM4E | |
| SCHEMBL7396691 | 0.80 | TSHR (0.36) | CYP1A2CYP2C9CYP3A4CYP2C19MAPT | |
| SCHEMBL7361675 | 0.80 | CA1 (0.41) | CYP1A2ALDH1A1FFAR1 | |
| SCHEMBL7399249 | 0.80 | GABBR2 (0.39) | CYP1A2CYP2C9CYP3A4CYP2C19TSHR | |
| SCHEMBL7400114 | 0.80 | SLC6A9 (0.41) | HDAC1CYP1A2CYP3A4ALDH1A1TSHR | |
| SCHEMBL7364859 | 0.80 | ANPEP (0.43) | CYP1A2ALDH1A1 | |
| SCHEMBL7365727 | 0.80 | SLC6A9 (0.41) | CYP1A2ALDH1A1FFAR1 | |
| SCHEMBL7362964 | 0.79 | FFAR1 (0.45) | FFAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |